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通络消癥汤治疗乙肝肝硬化代偿期肝郁脾虚夹瘀证的临床效果观察 预览

Observation on Clinical Effect of Tongluoxiaozheng Decoction in Treating Syndromes of Liver Depression and Spleen Deficiency with Stasis in Compensation Period of Hepatitis B Cirrhosis
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摘要 目的:探讨运用通络消癥汤治疗乙肝肝硬化代偿期肝郁脾虚夹瘀证的临床效果.方法:选取2015年1月—2016年1月我院收治的81例乙肝肝硬化代偿期肝郁脾虚夹瘀证患者的临床资料,按治疗方案的不同分为观察组与对照组,对照组38例,采用常规的西药抗病毒治疗;观察组43例,在对照组基础上联合通络消癥汤(1剂/天,分早晚2次口服)治疗.比较两组的临床疗效、治疗前后肝功能、肝门脉内径与脾脏厚度、血清肝纤维化指标及不良反应情况.结果:观察组治疗总有效率明显高于对照组,差异有统计学意义(P<0.05);治疗后两组证候积分均显著下降,且观察组显著低于对照组,差异有统计学意义(P<0.05);治疗后观察组肝功能及肝纤维化相关指标均显著优于对照组,差异有统计学意义(P<0.05);治疗后两组脾脏厚度及门脉内径均显著缩小,且观察组明显小于对照组,差异有统计学意义(P<0.05);两组均无明显不良反应发生.结论:通络消癥汤治疗乙肝肝硬化代偿期肝郁脾虚夹瘀证的疗效显著,且安全性较高,值得临床推广. Objective:To investigate the clinical effect of tongluoxiaozheng decoction in treating syndromes of liver depression and spleen deficiency with stasis in the compensation period of hepatitis B cirrhosis.Methods:The clinical data of 81 patients with syndromes of liver depression and spleen deficiency with stasis in the compensation period of hepatitis B cirrhosis admitted to our hospital from January 2015 to January 2016 were selected.The patients were divided into an observation group and a control group according to different treatment options.38 cases in the control group were given antiviral treatment with conventional Western medicine,and 43 cases in the observation group were treated with tongluoxiaozheng decoction(1 dose/day,2 times in the morning and evening)on the basis of the control group.The clinical effcacy,liver function,hepatic portal vein diameter and spleen thickness,serum fibrosis indexes before and after treatment and adverse reactions were compared between the two groups.Results:The total effective rate in the observation group was significantly higher than that in the control group,with statistically significant difference(P<0.05).The syndrome scores in the two groups were significantly decreased after treatment,and the scores in the observation group were significantly lower than those in the control group,with statistically significant differences(P<0.05).The liver function and liver fibrosis-related indexes in the observation group were significantly better than those in the control group,with statistically significant differences(P<0.05).The spleen thickness and portal vein diameter in the two groups were significantly reduced after treatment,and these indexes in the observation group were significantly smaller than those in the control group,with statistically significant differences(P<0.05).There were no obvious adverse reactions in the two groups.Conclusion:The tongluoxiaozheng decoction is effective and safe in the treatment of syndromes of liver depression and spleen deficiency with s
作者 闫宗光 Yan Zong-guang(Department of Infectious Diseases,Infectious Diseases Hospital of Kaifeng,Kaifeng,Henan 475001,China)
出处 《中国合理用药探索》 CAS 2019年第1期89-92,共4页 China Licensed Pharmacist
关键词 乙肝肝硬化 肝郁脾虚夹瘀证 通络消癥汤 Hepatitis B Cirrhosis Liver Stagnation and Spleen Deficiency Syndrome with Stasis Tongluoxiaozheng Decoction
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  • 1危北海,张万岱,陈治水,张育轩.肝硬化中西医结合诊治方案[J].现代消化及介入诊疗,2005,10(2):119-121. 被引量:69
  • 2陈立刚,迟宝荣.血浆神经肽Y水平测定在判定慢性肝脏疾病病变程度及预后中的意义[J].吉林大学学报:医学版,2006,32(1):113-115. 被引量:6
  • 3中医药学名词审定委员会.中医药学名词[S].北京:科学出版社,2005:58-81. 被引量:3
  • 4中华人民共和国卫生部.中药新药临床研究指导原则[S].北京:中国医药科技出版社,2002.68-74. 被引量:751
  • 5Miyazawa Y, Fukuda Y, Imoto M, et al.Immunohistochemical studies on the distribution of nerve fibers in chronic liver diseases [J]. Am J Gastroenterol,1988,83(10):1108-1114. 被引量:1
  • 6Buekwalter JB, Hamann JJ, Clifford PS. NeuropeptideY1 receptor vasoconstriction in exercising canine skeletal muscles [J]. Appl Physiol, 2005,99(6):2115 -2120. 被引量:1
  • 7Kalra SP, Kalra PS. NPY and cohorts in regulating appetite, obesity andmetabolic syndrome: beneficial effects of gene therapy. Neuropeptides, 2004,38(4): 201-211. 被引量:1
  • 8Ishida H, Shirayama Y, Iwata M, et al. Infusion of neurop-eptide Y into CA3 region of hippocampus produces antide-pressant-like effect via Y1 receptor[J]. Hippocampus, 2007,17(4): 271-280. 被引量:1
  • 9Hou C, Jia F, Liu Y, et al. CSF serotonin, 5-hydroxyindol-acetic acid and neuropeptide Y levels in severe major de-pressive disorder [J]. Brain Research, 2006, 1095(1): 154-158. 被引量:1
  • 10Widdowson PS, Ordway GA, Halaris AE. Reduced neurop-eptide Y concentrations in suicide brain [J]. Journal of Neuro-chemistry, 1992. 59(1): 73-80. 被引量:1

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