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纤溶指标对弥漫性血管内凝血的诊断价值 预览 被引量:5

Value of diagnostic indices of fibrinolysis in diffuse intravascular coagulation
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摘要 [目的]探讨弥漫性血管内凝血(DIC)敏感性和特异性较高的诊断指标应用于临床。[方法]选用BPC、PT、Fbg、APTT、DIC过筛诊断指标,3P、D-D二聚体、TT、FDP、ELT、ATⅢC、α2MG、VWFAg、乙醇胶、红细胞碎片确诊诊断指标,对1629例DIC各期病人及正常对照组进行检测比对分析,找出相关性。[结果]DIC前状态最敏感的指标是3P、ATⅢC、VWFAg,异常率高达100%;其次D-D二聚体,异常率为98.5%;BPC、PT、APTT半数以上异常,Fbg仅有1/3异常,其余各项指标敏感性较差;在消耗性低凝期VWFAg异常率持续增高,BPC、PT、TT异常率明显升高,而3P、ATⅢC、α2MG仅呈不同程度的增加;纤溶凝衰期时,FDP、ELT、D-D二聚体、红细胞碎片异常率高达100%,其他各项指标均有不同的异常改变。[结论]纤溶指标3P、D-D二聚体、ATⅢC可做DIC高凝前状态的诊断指标,BPC、PT、Fbg、VWFAg可做DIC过筛诊断指标,纤溶指标D-D二聚体、FDP、ELT、α2MG红细胞碎片可做DIC纤溶凝衰期诊断指标。因此,纤溶指标对DIC早期诊断及分型确诊诊断有重要实用价值。 [Objective] To explore the higher diagnostic indices in sensibility and specificity to apply to clinic.[Methods] We selected the sieving diagnostic indices such as BPC,PT,Fbg,APTT,DIC and the final diagnostic indices such as 3P,D-D dimer,TT,FDP,ELT,ATⅢC,α2MG,VWFAg,Alcohol mastic、bib to mesure a total of 1629 patients who were in different stages of DIC or normal comparison and find dependablities.[Results] The most sensitive indices before DIC were 3P,ATⅢC,VWFAg,and its anomal rate reached up to 100%.Of fib...
作者 王衍晶 高霞 白洪涛 赵成艳 WANG Yan-jing1; GAO Xia1; BAI Hong-tao1; ZHAO Cheng-yan2(1.Department of Clinical Laboratory; the First Affiliated Hospital of Dalian Medical University; Dalian 116011; China; 2.Department of Clinical Laboratory; the Second Affiliated Hospital of Dalian Medical University; Dalian 116027; China);
出处 《大连医科大学学报》 CAS 2009年第1期,共3页 Journal of Dalian Medical University
关键词 纤溶指标 DIC 分期 诊断 fibrinolysis index DIC grouping staging dignosis
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