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熊果酸的4-氯半乳糖衍生物的合成 预览 被引量:2

Synthesis of the Derivatives of Ursolic Acid 4-Chlorogalactose
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摘要 以α-D-三乙酰基-1-溴-4-氯半乳糖为原料,经Koenigs-Knorr反应、酯化反应,得到3-O-β-D-三乙酰基-4’-氯半乳糖熊果酸乙酯(UA2)、3-羟基-28-O-β-D-三乙酰基-4'-氯半乳糖熊果酸酯(UA5)和3-O-β-D-三乙酰基-4’-氯半乳糖熊果酸-28-O-β-D-三乙酰基-4'-氯半乳糖酯(UA8);研究了熊果酸衍生物脱乙酰基的条件,实验表明,在稀盐酸条件下得到4-氯半乳糖的2位保留乙酰基的产物,在固体氢氧化钠条件下得到全脱乙酰基的产物;共合成了9个熊果酸的4-氯半乳糖衍生物,所有目标化合物均为新化合物,其结构经NMR得以确认. With triacetyl-bromide-4-chlorogalactose,through Koenigs-Knorr reaction and esterifi-cation reaction,3-O-β-D-triacetyl-4 -chlorogalactose ursolic ethyl ester(UA2),3-hydroxy-28-O-β-D-triacetyl-4'-chlorogalactose ursolic ester(UA5),and 3-O-β-D-triacetyl-4 -chlorogalactose ursolic acid-28-O-β-D-triacetyl-4'-chlorogalactose ester(UA8) are synthesized.The condition of deacetylation is studied,2-acetyl-4-chlorogalacose is obtained in dilute hydrochloric acid,and all deacetylated products are obtained in sodium hy...
作者 张雁冰 刘丰五 王克让 张赛扬 蒋莹 刘宏民 ZHANG Yan-bing1; LIU Feng-wu1; WANG Ke-rang2; ZHANG Sai-yang1; JIANG Ying2; LIU Hong-min1(1.School of Pharmaceutical Sciences; Zhengzhou University; Zhengzhou 450001; China; 2.Department of Chemistry; China);
出处 《郑州大学学报:理学版》 CAS 北大核心 2009年第2期共5页 Journal of Zhengzhou University:Natural Science Edition
基金 国家自然科学基金资助项目,编号20472075
关键词 熊果酸 4-氯半乳糖 Koenigs-Knorr反应 脱乙酰基 ursolic acid 4-chlorogalactose Koenigs-Knorr reaction deacetylation
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