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原发性肺非霍奇金淋巴瘤的影像学表现及其病理学基础对照研究 预览 被引量:5

Radiologic-Pathologic Study on Primary Pulmonary Non-Hodgkin's Lymphoma
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摘要 目的通过探讨原发性肺非霍奇金淋巴瘤(PPNHL)的影像学表现及病理学特征之间的关联性,以提高此病的诊断准确率。方法对照分析22例PPNHL患者的临床病理特征及其胸部CT表现。结果组织病理学示低级别分化淋巴瘤12例,均为黏膜相关淋巴组织型(MALT型)淋巴瘤,占54.5%,呈小淋巴样细胞的弥漫浸润。胸部CT检查除1例(8.3%)为多发病灶外,其余11例(91.7%)均呈外周单发病灶,主要沿支气管黏膜下蔓延,形成肺内结节或肿块影8例(66.7%),部分周边有"晕征";斑片状肺炎影4例(33.3%);伴支气管充气征者7例(58.3%)。中高级别分化淋巴瘤10例,占45.5%。胸部CT呈单发病灶者4例,占40%;多发性病灶6例,占60%。其中肺内结节或肿块影4例(40%),浸润影1例(10%),混合型5例(50%),伴单侧胸腔积液5例(50%),伴肺门/纵隔淋巴结肿大2例(20%),伴肺不张3例(30%),伴小叶间隔增厚等间质性改变2例(20%)。结论 PPNHL的病理学基础决定其影像学表现具有一定特征,低级别分化PPNHL以外周局灶性实变区、支气管充气征为其特征性改变。高级别分化淋巴瘤更多表现为肺间质改变为主或与结... Objective To investigate the relevance of primary pulmonary non-Hodgkin's lymphoma(PPNHL) imaging with pathology features,so as to improve the diagnostic accuracy.Methods Twenty-two patients of PPNHL were scanned by chest computed tomography,and the results of clinical and pathology features were analyzed.Results The resulting pathologic examination showed that all patients in 12 cases of low-grade lymphoma had MALT lymphoma(54.5%),histologically with slightly atypical small lymphocyte proliferated.The radiological findings indicated unilateral peripheral lesion which extended along mucous membrane in 11 patients(91.7%) and multilateral lesion in only 1 patients(8.3%).CT features were ill-defined nodule or mass with halo sign(n=8,66.7%),patchy infiltrate(n=4,33.3%),and ill-defined consolidations with air-bronchograms(n=7,58.3%).The resulting pathologic examination showed that 10 patients were high and middle-grade lymphoma(45.5%).The radiological findings indicated unilateral lesion in 4 patients(40%) and multilateral lesion in 6 patients(60%).CT features were ill-defined nodule or mass(n=4,40%),patchy infiltrate(n=1,10%),mixed manifestation(n=5,50%),pleural effusion(n=5,50%),hilar and mediastinal lymph node enlargement(n=2,20%),atelectasis(n=3,30%),and pulmonary interstitial with interlobular septal thickening(n=2,20%).Conclusions The imaging features of PPNHL rely on its' basic pathology.Low-grade lymphoma is characterized by peripheral focal consolidation with air-bronchograms.High and middle-grade lymphoma is characterized by mixed manifestation of interstitial change and nodular focus.Analyzing CT features seriously may be helpful for diagnosis of PPNHL.
出处 《中国呼吸与危重监护杂志》 CAS 2011年第2期 171-175,共5页 Chinese Journal of Respiratory and Critical Care Medicine
关键词 淋巴瘤 断层摄影 X线计算机 病理学 诊断 Lymphoma Tomography X-ray computer Pathology Diagnosis
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参考文献13

  • 1成向阳,熊信国,陈汉章,李树本,何建行,邱源.原发性肺淋巴瘤21例诊断与治疗[J].中国现代医学杂志,2009(11):1742-1745. 被引量:9
  • 2周建军,丁建国,周康荣,王建华,曾蒙苏,程伟中.结外淋巴瘤:影像学共性特征与病理的关系[J].临床放射学杂志,2007,26(6):618-622. 被引量:68
  • 3姚伟强.原发性肺恶性淋巴瘤的治疗:附10例报告[J].中华放射肿瘤学杂志,1998,7(2):75-77. 被引量:7
  • 4L. J. King,S. P. G. Padley,A. C. Wotherspoon,A. G. Nicholson.Pulmonary MALT lymphoma: imaging findings in 24 cases[J]. European Radiology . 2000 (12) 被引量:1
  • 5Nestor LM,Richard SF,Kyung SL,et al.Diseases of the Lung:Radiologic and Pathologic Correlations. . 2006 被引量:1
  • 6Ooi GC,Chi m CS,Lie AK,et al.Computed tomography features of pri mary pul monary non-hodgkin‘s lymphoma. Clinical Radiology . 1999 被引量:1
  • 7L‘Hoste RJ Jr,Filippa DA,Lieberman PH,et al.Primary pulmonary lymphomas.A clinicopathologic analysis of 36 cases. Cancer . 1984 被引量:1
  • 8North LB,Libshitz HI,Lorigan JG.Thoracic lymphoma. Radiologic Clinics of North America . 1990 被引量:1
  • 9Lee DK,Im JG,Lee KS,et al.B-cell lymphoma of bronchus-associated lymphoid tissue (BALT)CT features in 10 patients. Journal of Computer Assisted Tomography . 2000 被引量:1
  • 10Carbone PP,Kaplan HS,Musshoff K,et al.Report of the committee on Hodgkin’s disease staging classification. Cancer Research . 1971 被引量:1

二级参考文献23

  • 1伍建蓉,郑玲,王晓毓,谷焰,张鸿彬.原发性结外淋巴瘤42例临床及误诊分析[J].临床肿瘤学杂志,2004,9(6):608-609. 被引量:11
  • 2王慧敏,韩宝惠,陈岗,何卫中.16例原发性肺淋巴瘤(BALT型)临床分析[J].肿瘤防治研究,2005,32(6):387-387. 被引量:9
  • 3ERRARO P, TRASTEK VF, ADLAKHA H, et al. Primary non-Hodgkin's lymphoma of the lung[J]. Thorac Surg, 2000, 69 (1): 993-997. 被引量:1
  • 4CORDIER JF, CHAILLEUZ E, LANQUE D, et al. Primary pulmonary lymphomas: a clinical study of 70 cases in nonimmuno- compromised patients[J]. Chest, 1993, 103(1): 201-208. 被引量:1
  • 5GANG L, HANSMANN M, ZWINGERS T, et al. Primary lymphomas of the lung: morphological, immunohistochemical and clinical features[J]. Histopathology, 1990, 16: 519-531. 被引量:1
  • 6L'HOSTE RJ, FILIPPA DA, LIEBERMAN PH, et al. Primary pulmonary lymphomas: a clinicopathological analysis of 36 cases [J]. Cancer, 1984, 54: 1397-1406. 被引量:1
  • 7CHONG EA, SVOBODA J, CHERIAN S, et al. Regression of pulmonary MALT lymphoma after treatment with rituximab [J]. Leuk Lymphoma, 2005, 46(9): 1383-1386. 被引量:1
  • 8FREDERIC VE, ELIE F, MARC P, et al. Role of Surgery in the Treatment of Primary Pulmonary B-Cell Lymphoma [J]. Ann Thorac Surg, 2007, 83: 236-240. 被引量:1
  • 9CZUCZMAN MS, WEAVER R, ALKUZWENY B, et al. Prolonged clinical and molecular remission in patients with low-grade or follicular non-Hodgkin's lymphoma treated with Rituximab plus CHOP chemotherapy: 9-year follow-up[J]. Clin Oncol, 2004, 22(23): 4711-4716. 被引量:1
  • 10Cordier JF,Chailleux E,Lauque D,et al.Primary pulmonary lymphoma.A clinical study of 70 cases in nonimmunocompromised patients.Chest,1993,103:201-209. 被引量:1

共引文献81

同被引文献53

  • 1陈晓霞,周彩存.原发性肺淋巴瘤18例分析[J].肿瘤,2007,27(6):496-498. 被引量:9
  • 2周建军,丁建国,周康荣,王建华,曾蒙苏,程伟中.结外淋巴瘤:影像学共性特征与病理的关系[J].临床放射学杂志,2007,26(6):618-622. 被引量:68
  • 3Thieblemont C, Bastion Y, Berger F, et al. Muca-associated lymphoid tissue gastrointestinal and nongastrointestinal lymphoma behavior: analysis of 108 patients. J Clin Oncol, 1997, 15:1624-1630. 被引量:1
  • 4Zucca E, Bertoni F, Roggero E, et al. The gastric marginal zone B-cell lymphoma of MALT type. Blood, 2000, 96:410-419. 被引量:1
  • 5Wotherspoon AC, Ortiz-Hidalgo C, FalzonMR, et al. Helicobacter pylofi-associated gastritis and primary B-cell gastric lymphoma. Lancet, 1991,338:1175-1176. 被引量:1
  • 6Du MQ, Isaccson PG. Gastric MALT lymphoma: from aetiology to treatment. Lancet Oncol, 2002, 3:97-104. 被引量:1
  • 7Isaaeson P, Wright DH. Malignant lymphoma of mucosa-associated lymphoid tissue. A distinctive type of B-cell lymphoma. Cancer, 1983, 52:1410-1416. 被引量:1
  • 8The Non-Hodgkin' s Lymphoma Classification Project. A clinical evaluation of the International Lymphoma Study Group classification of non-Hodgkin' s lymphoma. Blood, 1997, 89:3909-3918. 被引量:1
  • 9Servitje O, Gallardo F, Estrach T, et al. Primary cutaneous marginal zone B-cell lymphoma: a clinical, histopathological, immunophenotypic and molecular genetic study of 22 cases. Br J Dermatol, 2002, 147 : 1147-1158. 被引量:1
  • 10Cahill M, Barnes C, Moriarty P, et al. Ocular adnexal lymphoma- comparison of MALT lymphoma with other histological types. Br J Ophthalmol, 1999, 83:742-747. 被引量:1

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