期刊文献+

不同基因型慢性丙型肝炎患者的早期病毒学应答及免疫状态研究

Early virological response and immuological status in chronic hepatitis C patients with different genotypes
收藏 分享 导出
摘要 慢性丙型肝炎(CHC)感染是引起肝硬化和肝细胞癌的主要原因之一[1].目前对CHC患者的标准治疗是聚乙二醇干扰素(PegIFN)与利巴韦林联合治疗,但只有部分患者可获得早期病毒学应答(EVR),并且仅有不到40%的患者可获得持续病毒学应答(SVR)[2].国内外指南和专家共识指出,获得EVR的患者经48周治疗可获得较高的SVR,治疗12周出现EVR可作为最终获得SVR的重要预测指标[3-4].我们对不同基因型CHC患者的EVR情况及免疫状态进行了研究,报道如下.
出处 《中华临床感染病杂志》 CAS 2013年第3期共3页
  • 相关文献

参考文献14

  • 1Kuiken C,Simmonds P. Nomenclature and numbering of the hepatitis C virus[J].Methods in Molecular Biology,2009.33-53. 被引量:1
  • 2de Felipe B,Leal M,Soriano-Sarabia N. HCV RNA in peripheral blood cell subsets in HCV-HIV coinfected patients at the end of PegIFN/RBV treatment is associated with virologic relapse[J].Journal of Viral Hepatitis,2009.21-27. 被引量:1
  • 3European Association for the Study of the Liver. EASL Clinical Practice Guidelines:management of hepatitis C virus infection[J].Journal of Hepatology,2011.245-264. 被引量:1
  • 4慢性丙型肝炎抗病毒治疗专家共识[J].中华实验和临床感染病杂志(电子版),2009(3):59-64. 被引量:66
  • 5病毒性肝炎防治方案[J].中华传染病杂志,2001,19(1):56-62. 被引量:1654
  • 6丙型肝炎防治指南[J].中华传染病杂志,2004,22(2):131-136. 被引量:215
  • 7洪忻,喻荣彬.丙型肝炎病毒逃避宿主免疫的机制[J].世界华人消化杂志,2005,13(6):772-775. 被引量:7
  • 8Scherzer TM,Hofer H,Staettermayer AF. Early virologic response and IL28B polymorphisms in patients with chronic hepatitis C genotype 3 treated with peginterferon alfa-2a and ribavirin[J].Journal of Hepatology,2011.866-871. 被引量:1
  • 9Oze T,Hiramatsu N,Yakushijin T. Pegylated interferon alpha-2b(Peg-IFN alpha-2b) affects early virologic response dosedependently in patients with chronic hepatitis C genotype 1 during treatment with Peg-IFN alpha-2b plus RBVavirin[J].Journal of Viral Hepatitis,2009.578-585. 被引量:1
  • 10Vanegas NO,Román JL,Febles MH. Treatment of chronic hepatitis C virus infection.A study of best predictors for response[J].Revista Espanola de Quimioterapia,2011.198-203. 被引量:1

二级参考文献82

  • 1丙型肝炎防治指南[J].临床肝胆病杂志,2004,20(4):197-203. 被引量:722
  • 2王齐欣 ,魏来 ,高燕 ,孙德贵 ,蒋栋 ,徐小元 ,陈红松 ,王宇 .丙型肝炎病毒感染自然过程中的准种变化[J].中华传染病杂志,2004,22(5):323-326. 被引量:12
  • 3洪忻,喻荣彬.丙型肝炎病毒逃避宿主免疫的机制[J].世界华人消化杂志,2005,13(6):772-775. 被引量:7
  • 4Cohen J.The scientific challenge of hepatitis C.Science,1999, 285:26-30. 被引量:1
  • 5Alexopoulou A,Dourakis SP.Genetic heterogeneity of hepatitis viruses and its clinical significance.Curr Drug Targets Inflamm Allergy,2005.4:47-55. 被引量:1
  • 6Sharpe AH,Wherry EJ,Ahmed R,et al.The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection.Nat Immunol,2007,8:239-245. 被引量:1
  • 7Mirjana Grujic,Christina Bartoldy,Melissa Remy,et al.The role of CD80/CD86 in generation and maintenance of functional virusspecific CD8~+ T cells in mice infected with lymphocytic choriomeningitis virus.J Immunol,2010,185:1730-1743. 被引量:1
  • 8Kasprowicz V,Schulze Zur Wiesch J,Kuntzen T,et al.High level of PD-1 expression on hepatitis C virus(HCV)-specific CD8~+ and CD4~+ T cells during acute HCV infection,irrespective of clinical outcome.J Virol,2008,82:3154-3160. 被引量:1
  • 9Yao ZQ,Ellis King,Deborah Prayther,et al.T cell dysfunction by hepatitis C virus core protein involves PD-l/PDL-1 signaling. Viral Immunol,2007,20:276-287. 被引量:1
  • 10Nakamoto N,Kaplan DE,Coleclough J,et al.Functional restoration of HCV-specific CD8~+ T cells by PD-1 blockade is defined by PD-1 expression and compartmentalization. Gastroenterology,2008,134:1927-1937. 被引量:1

共引文献1931

投稿分析

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部 意见反馈