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恶性肿瘤临终患者血浆D-二聚体动态检测回顾性分析 预览 被引量:9

A Retrospective Analysis of Continuous Detection of Serum D-dimer in Malignancy Dying Patients
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摘要 目的分析恶性肿瘤临终患者死亡前血浆D-二聚体含量的变化与预后的关系。方法检测72例恶性肿瘤临终患者死亡前0~4周内和4~8周内自身血浆D-二聚体值,两次检测间隔时间平均为24天,并对两次检测值进行统计分析。结果恶性肿瘤临终患者死亡前0~4周D-血浆二聚体检测水平显著高于4~8周检测水值,差异有统计学意义(P=0.002);其中消化道恶性肿瘤差异最为明显(P=0.004),其次为肺癌(P=0.028)。然而男性和女性之间,不同年龄组间的D-二聚体变化值无明显差异(P】0.05)。结论血浆D-二聚体变化情况可以作为恶性肿瘤临终患者预后判断的参考指标。 Objective To analyze the relationship between change in plasma D-dimer levels and prognosis of dying patients with malignant tumors. Methods The plasma D-dimer levels of 72 malignant tumor patients were measured within 0-4 weeks and 4-8 weeks before their death. The average period between these two tests was approximately 24 days apart,and the results were statistically analyzed. Results In general, the plasma D-dimer level measured in 0-4 weeks was signifi cantly higher than that in 4-8 weeks(P=0.002), with gastrointestinal malignancies having the most signifi cant difference(P=0.004), followed by lung cancer( P=0.028). However, the difference of the D-dimer levels were similar between men and women and among different age groups(P>0.05). Conclusion The plasma D-dimer levels measured at different times could be used to predict the prognosis of dying patients with malignant tumors.
作者 张西 方珏敏 陈依静 王辉 许青 ZHANG Xi;FANG Juemin;CHEN Yijing;WANG Hui;XU Qing;Department of Medical Oncology,Shanghai Tenth People’s Hospital,Tongji University,School of Medicine;
出处 《肿瘤防治研究》 CAS CSCD 北大核心 2014年第4期350-352,共3页 Cancer Research on Prevention and Treatment
基金 上海市科学技术委员会科研计划基金资助项目(11411950602) 上海市第十人民医院优秀学科带头人培养计划资助项目(12RD102) 院特色专科课题资助项目(12ZD323)
关键词 D-二聚体 恶性肿瘤 动态检测 预后 D-dimer Malignancy Continuous detection Prognosis
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