The activatory effect of the Mech extract of Chai Hu, Bupleurum Chinese DC, on adenylate cyclase in mouse hepatocyte preparation (ACHP) was reported by us Recently we have been investigated that the isolation of the active fractions of Chai Hu by monitoring its activatory or inhibitory activities on the ACHP. The results showed that the isolated fractions of Chai Hu still has the activatory effect on the ACHP. And we firstly founde that two isolated fractions, named CH-5 and CH-7, have the inhibitory effects on the ACHP significantely. CH-5 and CH-7 inhibite the ACHP in a concentraction depentent manner.
Pharmacology and Clinics of Chinese Materia Medica
Bupleurum Chinese DC
Enzyme inhibition and activation