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结直肠癌肝转移的转化治疗策略 预览 被引量:3

Therapeutic options for colorectal cancer liver metastasis
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摘要 结直肠癌是临床常见的恶性肿瘤,约25%的患者在初诊时即发现结直肠癌肝转移,其余25%~50%的患者在后续治疗过程中最终发展为肝转移。肝转移是结直肠癌患者的首要死亡原因。近年来,CRLM的多学科综合治疗理念已经成为国内外共识,但手术切除转移灶仍是目前有望治愈CRLM的惟一手段。目前,仅有10%~15%的CRLM初始可切除,其余肝转移灶为初始不可切除。因此,如何将初始不可切除CRLM转化为可切除CRLM,是当前的研究热点。本文概述了结直肠癌肝转移的治疗原则以及转化治疗策略。 Colorectal cancer is one of the most frequent malignant neoplasms.Up to 25%of patients with primary colorectal cancer have already liver metastatic disease at the time of diagnosis.Untreated patients with liver metastases share a poor prognosis with an average survival of 12 months.In contrast, patients whose metastatic lesions are surgically treated have an average 5-year survival rate of 40%.Only 10-15%of initial colorectal liver metastases are considered as being resectable.In the remaining patients, the current trend is to downstage initially unresectable metastases by neoadjuvant therapy ( systemic or regional chemotherapy, portal vein embolization-PVE-or hepatic artery chemoembolization),tumor ablation and two-stage hepatectomy, alone or in combinations.This study reviews the current therapeutic options for colorectal liver metastases and their contribution to improve survival rates.
作者 黄忠诚 苏冀 HUANG Zhong-cheng SU Yi
出处 《中华结直肠疾病电子杂志》 2013年第5期共4页
关键词 结直肠肿瘤 肿瘤转移 转化治疗 Colorectal neoplasms Neoplasm metastasis Conversion therapy
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参考文献14

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