期刊文献+

儿童病毒性脑炎62例临床及病毒病原学分析 被引量:13

Clinical analysis and pathogenic study on 62 cases of encephalitis in childhood
分享 导出
摘要 目的探讨不同年龄组儿童病毒性脑炎临床表现差异及脑脊液病毒病原学特点。方法选取首都儿科研究所2002年1月至2003年2月收治的62例病毒性脑炎患儿,根据年龄分为A组(<3岁)、B组(3—6岁)、C组(>6岁)3组。(1)分析不同年龄组临床表现特点。(2)应用多重引物PCR方法对脑脊液进行病毒病原学检测,包括肠道病毒(EV)、疱疹病毒(HSV)Ⅰ、Ⅱ型、EB病毒、巨细胞病毒(12MV)5种。结果(1)3组患儿均有发热、嗜睡、烦躁、淡漠等症状;其他伴随症状:A、B两组患儿中24例(62.5%)伴有惊厥,C组中22例(95.7%)伴随头痛。(2)脑脊液病毒病原检测阳性者39例(62.9%),其中。EV18例(46.2%),HSVⅡ型9例(23.1%),CMV、EB病毒各6例(各15.4%),HSVⅠ型未检出。结论(1)除发热、嗜睡以外不同年龄组病毒性脑炎患儿伴随症状不同。(2)应用多重引物PCR方法早期检测脑脊液病毒病原阳性率较高。 Objective To investigate the difference of clinical manifestation among different groups of age in childhood and probe into pathogenic characteristics in CSF.Methods (1)Analyze the clinical manifestations among the different groups of age.(2)The DNA or RNA of EV、HSV Ⅰ、HSV Ⅱ、CMV、EB were determined by PCR in the cerebrospinal fluid(CSF) in 62 cases of encephalitis in childhood.Results (1)The clinical manifestations included fever,winking,fret,indifference in three groups.Other accompanying symptoms:24 cases (62 5%) had seizure in group A and B;22 cases (95 7%) had headache in group C.(2)The positive rate of pathogen in CSF was 62 9%(39),in which EV was 46 2% (18), HSV Ⅱ was 23% (9),CMV was 15 4% (6),EB was 15 4% (6).Conclusion (1)The accompanying symptoms are different among different age groups except fever,winking,fret,and indifference.(2)The positive rate is higher to detect pathogen in CSF with PCR in early encephalitis.
作者 蔡虹 王立文 朱彦丽 吕凌云 徐光芝 朱汝南 邓洁 赵林清 钱渊 Cai Hong,Wang Liwen,Zhu Yanli,et al.Capital Institute of Pediatrics,Beijing 100020,China
机构地区 首都儿科研究所
出处 《中国实用儿科杂志》 CSCD 北大核心 2004年第7期415-416,共2页 Chinese Journal of Practical Pediatrics
关键词 病毒性脑炎 临床表现 多重引物PCR法 病毒病原学 Encephalitis Clinical manifestation PCR Pathogenic
  • 相关文献

参考文献4

  • 1Yamamoto T,Nakamura Y.A single tube PCR assay for simultaneous amplification of HSV-1/-2,VZV,CMV,HHV-6A/-6B,and EBV DNAs in cerebrospinal fluid from patients with virus-related neurological diseases.J Neurovirol,2000,6(5):410-419 被引量:2
  • 2Munoz-Almagro C,Gonzalez-Cuevas A,Cambra FJ,et al.Rapid diagnosis of herpetic meningoencephalitis by PCR.Enferm Infet Microbiol Clin,2002,20(3):110-121 被引量:2
  • 3吴瑞萍 胡亚美 江载芳.诸福棠实用儿科学(第7版)[M].北京:人民卫生出版社,2002.2170. 被引量:24
  • 4金玉,余唯琪,薛君莉,李宇宁,林丽星.小儿病毒性脑膜炎病原诊断与临床分析[J].临床儿科杂志,2003,21(3):149-151. 被引量:32

共引文献54

同被引文献120

引证文献13

二级引证文献90

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部 意见反馈