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龙胆泻肝汤对小鼠的镇痛作用 预览 被引量:15

Analgesic Effects of Longdan Xiegan Decoctions on Mice
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摘要 目的:观察龙胆泻肝汤的镇痛作用.方法:(1)扭体法:腹腔注射0.6%的醋酸使小鼠产生剧烈疼痛而出现扭体反应.记录腹腔注射醋酸后15 min内小鼠的扭体反应数.(2)热板法:将筛选合格的小鼠在给药后0.5,1,2 h置于热板[温度为(55.0±0.5)℃]上,记录小鼠因热刺激产生疼痛反应的潜伏期.结果:龙胆泻肝汤能明显减少小鼠的扭体反应数;显著延长给药后(热板法)1,2 h小鼠疼痛反应的潜伏期.结论:龙胆泻肝汤具有显著的镇痛作用. Objective:To investigate the analgesic effects of Longdan Xiegan Decoctions on mice.Methods:Two kinds of animal pain models were prepared.(1)Torsion response:The Torsion response was induced by the drastic pain after intraperitoneal injection of 0.6% acetic acid.The number of torsion response was recorded within 15 minutes after intraperitoneal injection of acetic acid.(2) Hot plate:The eligible mice (after screening)were put on the hot plate (its temperature is at 55.0± 0.5℃) alone at 0.5 h,1 h,2 h after last administration.The latent period of pain response also was recorded.Results:The Longdan Xiegan Decoctions could obviously reduce the numbers of torsion response and markedly prolonge the latency of pain response at 1 h,2 h.Conclusion:These results suggest that the Longdan Xiegan Decoctions have significant analgesic effects.
作者 蒲维娅 PU Wei-ya (Pharmacy Section,Jiangsu Provincial TCM Hospital,Nanjing, Jiangsu,210029, China)
机构地区 江苏省中医院
出处 《时珍国医国药》 CAS CSCD 2004年第7期 389-390,共2页 Lishizhen Medicine and Materia Medica Research
关键词 龙胆泻肝汤 镇痛作用 药理作用 动物实验 Longdan Xiegan Decoctions Analgesic effect Pharmacological action Animal experiment
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