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消化道肿瘤腹腔化疗效果及不良反应观察 预览 被引量:2

The Curative Effect and Safety of Intraperitoneal Chemotherapy on Gastrointestinal Tract Cancer
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摘要 目的研究晚期消化道恶性肿瘤腹腔化疗的疗效及不良反应.方法37例晚期消化道肿瘤病人,采取单针腹腔穿刺,腹腔用药:5-氟脲嘧啶(5-Fu)1 000 mg/m2,顺铂(DDP)80~100mg/m2,足叶乙甙(Vp-16)200 mg/m2,每3周为一周期,化疗4~6周期.结果总有效率32.4%,中位生存期12.6月,1年生存率为35.1%,2年生存率为12.5%,最长1例生存达39个月,无严重毒性反应发生.结论本组采用单次穿刺腹腔联合化疗,操作安全简便,有效率较高,而毒副反应较轻,可望使晚期消化道肿瘤患者的化疗适应范围增加,使更多病人能提高生存质量及生存期. Objective To evaluate the curative effect and safety of intraperitoneal chemotherapy on advanced gastrointestinal tract cancer Methods 37 patients with advanced gastrointestinal tract cancer,adopting single_needle abdomen puncturing to chemotherapy:5_Fluorouracial (5_Fu) 1 000 mg/m 2, Cisplatin (DDP) 80~100 mg/m 2,Etoposide (Vp_16) 200 mg/m 2 Results Total rate of efficacy was 32 4% Median subsistence period was 12 6 months The longest one was 39 months The rate of one_year_subsistence was 35 1%,two_year was 12 5% There was no serious toxicity responds Conclusions The group adopting single_needle abdomen puncturing to chemotherapy,the operation was safe and simple,the efficiency was higher,but the vice_reaction in poison was lighter It is possible for us to enlarge the suitable chemotherapy range to patients with advanced gastrointestinal tract cancer, and to make more patients improve the quality of life and last the period of existence
作者 凌华晃 黄锡梅 苏炳光 蔡茂德 Ling Huahuang,Huang Ximei,Su Bingguang,Cai Maode (Department of Tumor Chemotherapy, People's Hospital of Gaozhou City, Gaozhou 525200,China)
出处 《河南肿瘤学杂志》 2004年第4期 260-261,共2页 Henan Journal of Oncology
关键词 消化道肿瘤 腹腔化疗 不良反应 gastrointestinal tract cancer intraperitoneal chemotherapy toxicity respond
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