[目的] 了解本市健康人群麻疹、腮腺炎、风疹的抗体水平. [方法] 采集0～50岁健康人群血标本543份,检测麻疹、腮腺炎、风疹抗体. [结果] 小于8月龄组麻疹抗体GMT最低,接种麻疹疫苗后抗体GMT显著升高(P<0.001);小于8月龄组及8月龄组风疹抗体水平最低,1岁接种疫苗后风疹抗体显著升高(P<0.001),但随着年龄的增长抗体水平有所下降,抗体阳性率维持在85%以上;小于8月龄组及8月龄组流行性腮腺炎抗体水平最低,1岁以上各年龄组抗体水平显著上升(P<0.001). [结论] 上海市现阶段实行麻疹疫苗、MMR疫苗的接种程序比较合理和有效,但应该进一步开展上海市育龄期妇女风疹抗体水平调查和MMR疫苗免疫持久性观察,研究预防未及龄儿童麻疹疫苗免疫策略、育龄期妇女接种风疹疫苗免疫策略,预防先天性风疹综合征.
Objective To understand the level of antibodies of measles mumps and rubella in healthy people after rubella vaccine and MMR in Shanghai. [Methods] 543 healthy people's sera from 0-50 years old were assayed for antibodies of measles,mumps and rubella. [Results] GMT of measles antibody was the lowest in babies less than 8 months, and in 8-month group rose markedly (P<0.001) after vaccination. Antibody of GMT < 8 months and 8-month were less than 1∶10, and antibody GMT of 1 year after vaccination rose markedly (P<0.001). Although the antibody level was decreasing with age, the positive rate still maintained above 85%. GMT of mumps antibody in <8 months and 8-month was less than 1∶5, it rose markedly one year after vaccination (P<0.001). [Conclusion] The results of analysis shows that the recent vaccination process of measles and MMR in Shanghai are comparatively reasonable and effective, but further researches of rubella antibody level and persistent observation of MMR vaccination are necessary for childbearing women. Meanwhile, studies on vaccination strategy of measles for pre-vaccinating child and childbearing women are both essential to prevent congenital rubella syndrome (CRS).
Shanghai Journal of Preventive Medicine