Objective To study the correlation between the antinucleosome antibody and the complement amount and the disease activity in the patients with systemic lupus erythematosis(SLE). Methods Antinucleosome antibody and the anti-ds-DNA antibody were evaluated in 46 SLE patients by ELISA. The concentrations of the immunoglobulin and the complement were measured using DADE Bering BNproSpec. The SLE patients was divided into two groups according to the antinucleosome antibody levels: the positive group (group A)and the negative group(group B). Results There was signi-ficant difference in the anti-ds-DNA antibody,C3,C4,IgG and systemic lupus erythematosus disease activity index(SLEDAI) between group A and group B(P<0.05) without differences in ESR,Hb,IgA,IgM(P>05),The serum antinucleosome antibody level was correlated negatively with C3(P<0.001),C4(P<0.05) and positively with SLEDAI(P<0.05). Conclusions The antinucleosome antibody plays an important role in the onset, development and diagnosis of SLE, which is promising to indicate the activity of SLE.
Journal of Diagnostics Concepts & Practice