The intravenous administration of arachidonate (0.5mg/kg) to rabbit offers a model of rapid, transient and repeatable rise of PAP associated with occlusive platelet aggregates in the microvasculature of the lungs. This model was convenient for the study of antiplatelet drugs. Intravenous administration of sodium ferulate (SF, 50mg/ kg) before arachidonate challenge prevented rise of PAP and decreased occlusive platelet aggregates in the microvasculature of the lung.. The results suggest that the metabolism of TXA2, PGI2 were inhibited and plasma cGMP level was increased both were responsible for the effect of against pulmonary embolism of sodium ferulate.
Basic Medical Sciences and Clinics
pulmonary embolic hypertension arachidonic acid sodium ferulate cyclic GMP