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0.05%地奈德乳剂治疗内源性湿疹的临床研究 预览 被引量:35

Clinic Study of Endogenous Eczema Treated by 0.05 % Desonide Cream
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摘要 目的评价0.05%地奈德乳剂治疗内源性湿疹包括特应性皮炎3周的疗效和安全性.方法入组包括特应性皮炎在内的内源性湿疹84例,采用随机、双盲、基质对照、平行组对比研究,受试者外涂药物于受累区域,2次/d,连续治疗3周.结果试验组靶皮损总积分(TSS)由治疗前8.31±1.85降至1.19±1.69,TSS改善84.99%;对照组TSS由8.43±1.67降至3.10±2.24,TSS改善63.54%.试验组与对照组靶皮损各项观察指标均得到改善,但试验组的改善优于对照组.总体改善评价试验组总有效率为80.95%,对照组为52.38%,两组比较差异有显著性(P<0.05).结论0.05%地奈德乳剂治疗内源性湿疹的临床治愈率、总体疗效优于基质,且不良反应发生率低,是一种安全有效的外用皮质类固醇激素. Objective To assess the effect and safety of 0.05% Desonide cream versus vehicle in 3 week treatment of endogenous eczema including atopic dermatitis. Methods 84 cases of endogenous eczema including atopic dermatitis were recruited.The creams were applied twice a day for 3 week.A randomized,double blind, vehicle control,parallel grouping trial was conducted. Results TSS of test group improved 84.99% was decreased from baseline 8.31±1.85 to 1.19±1.69,TSS of control group improved 63.54% was decreased from 8.43±1.67 to 3.10±2.24. Every observating mark in both groups were improved,though the improvement was greater in test group than control group.In general improvement assess,total response rate was 80.95% in test group and 52.38% in control group.There was significant difference of response rate( P <0.05)between two groups.Conclusion Desonide cream is safe and effective external use corticosteroid, which clinical cure rate and general efficacy in treating endogenous eczema is better than that of vehicle,and the side effect is low.
作者 毕新岭 顾军 高春芳 BI Xin ling,GU Jun, Gao Chun fang (Department of Dermatology, Changhai Hospital,the Second Military Medical University, Shanghai 200433,China) 
出处 《中国皮肤性病学杂志》 CAS 北大核心 2004年第12期 721-722,731,共3页 The Chinese Journal of Dermatovenereology
关键词 地奈德乳剂 湿疹 内源性 Desonide cream Eczema Endogenous
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参考文献3

  • 1MacKenzie -Wood AR, Freeman S. Unclassified endogenous eczema[ J ]. Contact Dermatitis, 1999,41:18 - 21. 被引量:1
  • 2Freeman S, Howard A, Foley P,et al. Efficacy, cutaneous tolerance and cosmetic acceptability of desonide 0.05 % lotion (Desowen) versus vehicle in the short-term treatment of facial atopic or seborrhoeic dermatitis[ J]. Australas J Dermatol, 2002,43:186 - 被引量:1
  • 3Lebrun-Vignes B, Legrain V, Amoric J, et al. Comparative study of efficacy and effect on plasma cortisol levels of micronised desonide cream 0.1% versus betamethasone dipropionate cream 0.05% In the treatment of childhood atopic dermatitis [ J ]. Ann Derm 被引量:2

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