Objective To assess the effect and safety of 0.05% Desonide cream versus vehicle in 3 week treatment of endogenous eczema including atopic dermatitis. Methods 84 cases of endogenous eczema including atopic dermatitis were recruited.The creams were applied twice a day for 3 week.A randomized,double blind, vehicle control,parallel grouping trial was conducted. Results TSS of test group improved 84.99% was decreased from baseline 8.31±1.85 to 1.19±1.69,TSS of control group improved 63.54% was decreased from 8.43±1.67 to 3.10±2.24. Every observating mark in both groups were improved,though the improvement was greater in test group than control group.In general improvement assess,total response rate was 80.95% in test group and 52.38% in control group.There was significant difference of response rate( P <0.05)between two groups.Conclusion Desonide cream is safe and effective external use corticosteroid, which clinical cure rate and general efficacy in treating endogenous eczema is better than that of vehicle,and the side effect is low.
The Chinese Journal of Dermatovenereology