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原发性肝癌介入治疗前后凝血及纤溶功能变化及临床意义 预览 被引量:5

Alternation and Clinical Significance of Blood Coagulation and Fibrinolytic Function Before and After the Interventional Therapy of Primary Hepatocellular Carcinoma
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摘要 目的研究原发性肝癌介入治疗前、后凝血及纤溶功能的变化.方法血浆凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)、纤维蛋白原含量(Fg)、凝血因子Ⅶ(FVⅡ)、凝血因子Ⅷ(FⅥI-Ⅱ)、因子X(FX)采用光散射比浊法.P-选择素(Ps),血管性血友病因子(vWF),尿激酶型纤溶酶原激活物(uPA)采用ELISA法测定.uPA抑制物(PAI)采用发色底物法.结果(1)与对照组比较,治疗前PT、APTT、TT、Ps、VWF、uPA升高,Fg、FⅦ、FⅧ、FX降低.(2)与治疗前比较,治疗后PT、APTT、Ps、vWF、uPA降低,FⅦ、FⅧ升高.(3)与对照组比较,治疗后PT、APTT、TT、Ps、vWF、uPA升高,Fg、FⅦ、FⅧ、FX降低.结论原发性肝癌患者血凝降低,纤溶亢进,血小板活化,介入治疗后减轻,但未恢复正常. Purpose To study the changes of blood coagulation and fibrinolytic function before and after interventional therapy of primary hepatocellular carcinoma. Methods To analyze prothrombin time(PT), activated partial thromboplastin time (APTT), thrombin time (TT), fibrinoger (Fg), coagulate factorVⅡ(FVⅡ),factorVⅢ(FVⅢ),factorX(FX) with the light scattering turbidimetry,and P-Selectin (Ps),Vou willebrand factor (vWF), urokinase profibrinolytic activating factor (uPA) were examined by ELISA, uPA' s inhibitor (PAI) with the chromogenic substances. Results 1. PT,APTT,TT,Ps, vWF and uPA in group before therapy were higher than those in control group, while Fg,FVⅡ,FVⅢ and FX in group before therapy were lower than those in control group.2. PT, APTT,Ps, vWF and uPA in group after therapy were lower than before therapy, while FVⅡand FVⅢin group after therapy were higher than before therapy. 3. PT, APTT,Ps,vWF and uPA in group after therapy were higher than those in control group, while Fg.FVⅡ, FVⅢ and FX in group after therapy were lower than those in control. Conclusions The blood coagulation of primary hepatoceEular carcinoma were decreased, the fibrinolysis was increased, platelet was activated, and abated after interventional therapy, but did not resume normal.
作者 张爱华 李小亮 孙达春 彭秀斌 梁翠微 黎义锦 ZHANG Ai-hua,LI Xiao-Hang, SUN Da-chun, PENG Xiu-bin, LIANG Cui-wei, LI Yi-jin Department of Laboratory Technology, Third Affiliated Hospital, Medical College of Jinan University-People’ s Hospital of Zhuhai, Zhuhai 519000, China
出处 《复旦学报:医学版》 CAS 北大核心 2005年第1期 18-20,29,共4页 Fudan University Journal of Medical Sciences
基金 广东省珠海市科技局科研项目
关键词 原发性肝癌 介入治疗 纤溶功能 凝血 APTT 升高 治疗后 PA 降低 PS primary hepatocellular carcinoma interventional therapy blood coagulation fibrinolysis platelet activation
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