4 lots of JE attenuated live vaccine manufactured by Chengdu Institute of Biological Products were used for a large-scale field trial among 580 000 of children aged 1~15 resided in Yun- nan Province. Of the children, 867 aged 1~6 were selected for measurement of body temperature and observation of systemic reaction for a period of 3 weeks. Only 17 of the 867 children showed irregular moderate fever (37.6~38℃), but it could not last for more than i day, and no other systemic reaction was found. Local reaction was mild. No adverse reaction was found in the other vaccinated children. The neutralizing antibody conversion rates of children vaccinated with 1 : 5, 1 : 10 and 1 : 50 diluted vaccine were 85% (GMT22.7, n=39), 71% (GMT31, n=35)and 68% (GMT14, n=34), respectively.
Chinese Journal of Bilogicals
JE attenuated live vaccine Safety Serological efficacy