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流行性乙型脑炎活疫苗大面积人体接种的安全性和血清学效… 预览 被引量:18

Observation of Safety and Serological Efficacy from Large-scale Field Trial on Japanese Encephalitis Live Vaccine
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摘要 用成都生物制品研究所生产的4批乙脑减毒活疫苗在云南省对58万1~15岁儿童进行大面积免疫观察,并对其中867名1~6岁儿童进行了体温测量和全身反应观察3周,仅17名儿童出现无规律性和体温中反应(37.6~38℃),但均未超过一天,亦未发生其它全身反应。局部反应轻微。其余接种对象均未发现疫苗引起的不良反应。接受1:5,1:10,1:50稀释疫苗的各组儿童中和抗体阳转率分别为85%(GMT 22.7,n=39),71%(GMT=31,n=35)和68%(GMT=14,n=34)。 4 lots of JE attenuated live vaccine manufactured by Chengdu Institute of Biological Products were used for a large-scale field trial among 580 000 of children aged 1~15 resided in Yun- nan Province. Of the children, 867 aged 1~6 were selected for measurement of body temperature and observation of systemic reaction for a period of 3 weeks. Only 17 of the 867 children showed irregular moderate fever (37.6~38℃), but it could not last for more than i day, and no other systemic reaction was found. Local reaction was mild. No adverse reaction was found in the other vaccinated children. The neutralizing antibody conversion rates of children vaccinated with 1 : 5, 1 : 10 and 1 : 50 diluted vaccine were 85% (GMT22.7, n=39), 71% (GMT31, n=35)and 68% (GMT14, n=34), respectively.
作者 马文信 俞永新 王寿贵 周本立 马云洪 俸淑英 陈品全 郝去非 张国铭 郭玉鹏 Ma Wenxin et al Chengdu Institute of Biological Products, Chengdu
出处 《中国生物制品学杂志》 CAS CSCD 1993年第4期 188-191,共4页 Chinese Journal of Bilogicals
关键词 安全性 血清学效果 乙脑 疫苗 JE attenuated live vaccine Safety Serological efficacy
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