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鼻咽癌与前列环素及血栓素关系初探 被引量:3

A preliminary approach to concentrations of plasma PGI_2 and TXA_2 in nasopharyngeal neoplasms
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摘要 用放射免疫法分别测定了34例鼻咽癌、16例良性瘤、12例炎症和16例正常周血浆中前列环素(PGI2)和血栓素A2(TXA2)的稳定代谢产物6-酮-前列腺素F1a(6-keto-PGF1a)和血栓素B2(TXB2)的含量。结果显示鼻咽癌患者血浆TXB2含量显著升高(P<0.01),PGI2含量所增加;TXB2/6keto-PGF1a比值显著增加(P<0.01)。鼻咽癌晚期患 者血浆TXB2含量显著高 A radioligand binding assay was used to evaluate the level of plasma TXB2 and 6-keto-PGF1a in 34 patients with carcinoma of nasopharynx. The results demonstrated that the level of 6-keto-PGF1a and TXB2 in plasma increased in patient with cancer cases as compared with normal controls, the level of TXB2;increased significantly(P< 0. 01 ). Also the level of TXB2 was significantly increased in plasma of advanced cases than those in primary cases(P<0. 01), These results suggested that the level of TXA2/PGI2,especially TXA2, should be implicated as possible facilitative agents in growth and dissemination of nasopharyngeal neoplasms.
作者 褚汉启 刘永强 Chu Hanqi;Tan Shenwei;Liu Yongqiang(Department of Otolaryngology, Tongji Hospital, Tongji Medical University, Wuhan)
出处 《临床耳鼻咽喉科杂志》 CAS 1994年第2期67-69,共3页 Journal of Clinical Otorhinolaryngology
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