目的探讨血浆同型半胱氨酸(Homocysteine ,HCY)水平与脑卒中之间的关系.方法检测健康人与脑卒中患者的血浆HCY水平,统计高HCY卒中患者与正常HCY卒中患者伴随的脑卒中危险因素状况,进行对比分析.结果脑卒中组HCY 水平(28.24±6.62)μmol/L,对照组(9.16±2.34)μmol/L,有显著差异(P＜0.05);脑卒中组高HCY血症发生率38%,对照组5%,有显著性差异(P＜0.01).高HCY卒中患者与正常HCY卒中患者伴随的吸烟、高血压病、糖尿病及高血脂症的状况无显著性差异(χ2=0.38,0.08,0.47,1.08;P＞0.05).结论脑卒中患者血浆HCY水平升高,高HCY血症是脑卒中的独立危险因素.
Objective To explore the relation between plasma homocysteine concentration and stroke. Methods Subjects with stroke (n=140) and healthy control subjects(n=40 ) were measured the plasme homocysteine concentration, the risk factors of stroke in patients with high homocysteine concentration and normal were analyzed. Results Plasma homocysteine concentration in the stroke patients (28.24±6.62)μmol/L were higher than that in the controls (9.16±2.34)μmol/L. The incidence of hyperhomocysteinemia in the stroke patients (38%) was obviously higher than that in controls (5%).As compared with the normal, there were no significant differences in stroke risk factors ,such as cigarette、smoking、hypertesion、diabetes and hyperlipidemia of stroke patients with high homocysteine (χ 2=0.38,0.08,0.47,1.08,P>0.05) .Conclusion The plasma homocysteine concentration is increased in stroke, plasma homocysteine concentration as a independent risk factor of stroke.