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甲状腺良性病变中TTF-1的表达 预览

Expression of TTF-1 gene product in benign thyroid lesions
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摘要 目的探讨甲状腺特异性转录因子-1(TTF-1)在甲状腺良性病变中的表达与甲状腺良性病变功能及病理特征之间的关系.方法采用免疫组化S-P法检测45例甲状腺良性增生性病变和19例正常甲状腺组织标本的TTF-1表达.结果TTF-1在甲状腺良性病变和正常组织的阳性表达率分别为64.4%和57.9%,彼此之间的TTF-1阳性表达差异无显著性(P>0.05),但良性病变中伴有乳头增生或微腺瘤形成及甲状腺腺瘤阳性表达率更高,差异有显著性(P<0.05).结论甲状腺良性病变中TTE-1阳性表达提示可能存在的功能性病灶和更明显的增生倾向,有助于我们对这些病变采取更为彻底的手术治疗. Objective To evaluate the relationship between the clinicopathological features and the expression of TTF-1 gene in thyroid benign diseases. Methods TTF-1 expression were determined by immunohistochemistry(S-P method) in 45 hyperplastic lesions(including 31 goiters,12 adenomas and 2 Graves diseases)and 19 normai tissue.Results The rate of positive expression of TTF-1 was 64.4% and 57.9% in hyperplastic lesions and normal tissue,respectively. There was no significant difference between the two groups (P>0.05); but The data showed that there was a higher positive expression among the lesions with papillae and microadenomas or adenomas(P <0.05).Conclusions The expression of TTF-1 suggests that there are functional focus and lesions with more active biological behavour in thyroid benign diseases.
作者 江现强 刘志明 陆云飞 赫军 JIANG Xian-qiang1, LIU Zhi-ming2, LU Yun-fei2,HE Jun1 1.Department of General Surgery, First Affiliated Hospital of Guangxi Traditional Medical Collage,Nanning 530021, China.2.Department of Gastrointestinal and Gland Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China
出处 《广西医学》 CAS 2005年第3期 332-334,共3页 Guangxi Medical Journal
关键词 甲状腺良性病变:甲状腺特异性转录因子-1 免疫组化 Thyroid benign disease TTF-1 Immunohistochemistry
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