BACKGROUND:The etiology and pathogenesis of Tourette syndrome(TS) is still unacknowledged,and related studies on the relationship between TS and hypoironemia are unavailable.Since hypoironemia has been found existed in children with TS who showed better outcomes after receiving adjuvant ferralium,thereby this study was designed to investigate the relationship between TS and serum iron. OBJECTIVE:To study the relationship between TS and serum iron. SETTING:At a nursing science department of a university-affiliated hospital,pediatric department of a university affiliated hospital and sectional hospital. PARTICIPANTS:Between June 1997 and December 2000,45 children with TS received treatment at pediatric clinic of Chenghai sectional people's hospital,Shantou city,who accorded with the diagnostic standards of the second edition of Chinese Psychopathy Category and Diagnostic Standards,those who were confirmed as brain organic diseases by CT and MIR were excluded. METHODS:Serum iron, hemoglobin and the number of red blood cells were determined in 45 TS children and compared with that in 38 controls. MAIN OUTCOME MEASURES:Difference of the level of serum iron and the incidence of hypoironemia between two groups. RESULTS: The level of serum iron was(12.79±0.67) μmol/L in experimental group, obviously lower than(19.26±5.38) μmol/L in control group(P< 0.005),the incidence of hypoironemia was 42%significantly higher than13%of control group(P< 0.005). CONCLUSION:Quite a lot of children with TS have hypoironemia that might be one of the pathogenesis factors,the possible mechanism is,as the result of hypoironemia,decreased activity of monoamine oxidase led to abnormal monoamine neurotransmitter.
Chinese Journal of Clinical Rehabilitation