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多发性抽动症患儿血清铁的变化比较分析 预览 被引量:5

Change of serum iron in children with Tourette syndrome
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摘要 背景:多发性抽动症的病因与发病机制尚未十分明了,至今还未发现有低铁血症与多发性抽动症发病关系的相关报道,在既往收治的多发性抽动症患儿中发现部分存在着低铁血症,辅以铁剂治疗后的症状改善较佳,为探讨多发性抽动症与血清铁之间的关系,特此设计该研究.目的:探讨小儿多发性抽动症与低铁血症之间的关系.单位:一所大学医学院护理学系,一所大学医学院附属医院儿科及一所区级医院儿科.对象:观察组45例为1997-06/2000-12汕头市澄海区人民医院儿科门诊收治的多发性抽动症患儿.均符合<中国精神疾病分类方案与诊断标准>第二版中关于多发性抽动症诊断标准,剔除符合上述表现但CT及MIR提示有脑器质性病变的患儿.方法:检测观察组45例多发性抽动症患儿的血清铁、血红蛋白及红细胞计数,并与对照组38例正常儿童进行比较分析.主要观察指标:两组之间血清铁水平的比较;两组之间低铁血症发生率的比较.结果:观察组的血清铁(12.79±0.67)μmol/L,低于对照组(19.26±5.38)μmol/L(P<0.005),低铁血症发生率为42%,高于对照组13%(P<0.005).结论:多发性抽动症患儿有相当一部分存在低铁血症,低铁血症可能是多发性抽动症的发病因素之一.其机制可能是低铁血症引起了单胺氧化酶活力下降,导致单胺类神经递质异常. BACKGROUND:The etiology and pathogenesis of Tourette syndrome(TS) is still unacknowledged,and related studies on the relationship between TS and hypoironemia are unavailable.Since hypoironemia has been found existed in children with TS who showed better outcomes after receiving adjuvant ferralium,thereby this study was designed to investigate the relationship between TS and serum iron. OBJECTIVE:To study the relationship between TS and serum iron. SETTING:At a nursing science department of a university-affiliated hospital,pediatric department of a university affiliated hospital and sectional hospital. PARTICIPANTS:Between June 1997 and December 2000,45 children with TS received treatment at pediatric clinic of Chenghai sectional people's hospital,Shantou city,who accorded with the diagnostic standards of the second edition of Chinese Psychopathy Category and Diagnostic Standards,those who were confirmed as brain organic diseases by CT and MIR were excluded. METHODS:Serum iron, hemoglobin and the number of red blood cells were determined in 45 TS children and compared with that in 38 controls. MAIN OUTCOME MEASURES:Difference of the level of serum iron and the incidence of hypoironemia between two groups. RESULTS: The level of serum iron was(12.79±0.67) μmol/L in experimental group, obviously lower than(19.26±5.38) μmol/L in control group(P< 0.005),the incidence of hypoironemia was 42%significantly higher than13%of control group(P< 0.005). CONCLUSION:Quite a lot of children with TS have hypoironemia that might be one of the pathogenesis factors,the possible mechanism is,as the result of hypoironemia,decreased activity of monoamine oxidase led to abnormal monoamine neurotransmitter.
作者 陈文 林广裕 吴毅 Chen Wen1,Lin Guang-yu2,Wu Yi3 1Department of Nursing,Medical College of Jinan University,Guangzhou 510631,Guangdong Province,China;2Department of Pediatrics,Second Affiliated Hospital,Medical College of Shantou University,Shantou 515000,Guongdong Province,China;3Department of Pediatrics,People’s Hospital of Chenghai District,Shantou City,Guangdong Province,Shantou 515000,Guangdong Province,China
出处 《中国临床康复》 CAS 北大核心 2005年第15期 252-253,共2页 Chinese Journal of Clinical Rehabilitation
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参考文献3

  • 1Liu ZS. Multiple tics. Beijing: People Health Press 2002: 32, 44 - 9 被引量:1
  • 2Singer HS, Hahn IH, Krowiak E, et al. Tourette's syndrome: a neurochemical analysis of postmortem cortical brain tissue. Ann Neurol 1990; 27:443 -6 被引量:1
  • 3Kaladhar M. Effects of iron deficiency on seroton in uptake in vitro by rat brain synaptic vesicles. J Nutr Chem 1982; 38:576 被引量:1

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