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探讨白细胞介素-8、白细胞介素-6和C-反应蛋白对慢性阻塞性肺疾病中气道炎症的影响 预览 被引量:61

Implication of Interleukin-8, Interleukin-6 and C-reactive Protein on Airway Inflammation in Chronic Obstructive Pulmonary Disease
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摘要 目的测定白细胞介素-8(IL-8)、白细胞介素-6(IL-6)和C反应蛋白(CRP)在慢性阻塞性肺疾病(COPD)平稳期患者血清中的浓度,探讨炎性介质对病程的影响. 方法 26例老年平稳期、病情严重度为Ⅱ级的慢性阻塞性肺疾病患者与31例对照组;采集外周血5ml离心,采用生物芯片技术测定(IL-8)、(IL-6)和散射浊度测定法CRP. 结果慢性阻塞性肺疾病组的IL-8明显高于正常对照组,差异有显著性;IL-6和C-反应蛋白较正常对照组比较差异无显著性. 结论白细胞介素-8在慢性阻塞性肺疾病平稳期的患者中有明显增高,提示它参与了COPD病程的进展,是气道炎症不可逆转的原因之一;白细胞介素-6、C-反应蛋白与对照组比较差异无显著性意义,表明白细胞介素-6、C-反应蛋白在COPD平稳期的病程中可能没有重要意义. OBJECTIVE To investigate the implication of interleukin-8(IL-8), interleukin-6(IL-6) and C-reactive protein(CRP) in the stable period of elderly patients of chronic obstructive pulmonary disease(COPD). METHODS Twenty six elderly patients in the stable period of COPD ( grade Ⅱ) and 31 normal controls were selected. Levels of IL-8, IL-6 and CRP in serum were detected by bio-chip and nephelometry, respectively. RESULTS The level of serum in COPD patients was higher than control group( P<0.05). And the levels of serum IL-6 and CPR were not significantly high in COPD group than those in control one. CONCLUSIONS In the stable period of COPD, the level of serum IL-8 is increased and it is possible involved the processes of chronic airway inflammation. IL-8 may be one of important cytokines in chronic airway inflammation in COPD. However the levels of serum IL-6 and CRP have no significant difference in COPD group than in control group that means they may not play an important role in the stable period of COPD.
作者 牟小芬 田亚平 郭广宏 王彩云 MOU Xiao-fen, TIAN Ya-ping, GUO Guang-hong, WANG Cai-yun (General Hospital of PLA, Beijing 100853, China)
机构地区 解放军总医院
出处 《中华医院感染学杂志》 CAS CSCD 北大核心 2005年第6期 615-617,共3页 Chinese Journal of Nosocomiology
关键词 白细胞介素 C-反应蛋白 气道炎症 慢性阻塞性肺疾病 Interleukin C-reactive protein Airway inflammation COPD
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