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国产雌二醇控释贴片治疗卵巢功能低落176例临床观察 被引量:1

The effects of the estradiol control deliverypatch in the treatment of 176 cases of ovarianfailure
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摘要 应用双盲法观察国产雌二醇控释贴片治疗卵巢功能低落104例(用药组),采用空白贴片治疗卵巢功能低落72例(对照组),并结合促黄体生成激素,促卵泡激素,雌二醇测定,阴道壁脱落细胞成熟指数和子宫内膜组织学检查综合评价药效,结果表明:用药组贴片对卵巢功能低落所致的潮热,出汁,阴道干涩,头晕,情绪波动及失眠等6项主要临床表现,有显著疗效,有效率分别为97.9%、97、5%、93、7%、77.0%、76.2% he effects of the estradiol control delivery patchmade in China on the main manifestation in the 176cases of ovarian failure patient were evaluated with theimprovement of their symptoms, the changes of serumlevels of LH, FSH, E2, the vaginal exfoliated cytologicmaturation index (MI) and the histological alterationof endometrium.The results indicated that the six main symptomsincluding hectic fever, sweating, vaginal dry andhardgoing, dizziness, emotioned lability and insom-nia were improved significantly and progressively withprolongation of the treatment. The effective rates were97.9%, 97.5%, 93.7%, 77.0%, 76.2%, 75.0%respectively form hectic fever to insomnia. Theinhibitory effects on serum LH. FSH levels occurredon the 10th day of the treatment. The MI increasedwithin whole course and the serum estradiol level ele-vated slightly and stably. There were no significantendometrial proliferation caused by the patch.
出处 《中华妇产科杂志》 CAS CSCD 北大核心 1994年第6期 346-349,共4页 Chinese Journal of Obstetrics and Gynecology
关键词 雌二醇 卵巢功能低落 治疗学 Estradiol ovarianismTherapeutics
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  • 2D. Arndts,K. Arndts. Pharmacokinetics and pharmacodynamics of transdermally administered clonidine[J] 1984,European Journal of Clinical Pharmacology(1):79~85 被引量:1

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