denocarcinoma, adenoma and dysplasia of the stomach of adult Wistar rats were induced following administration of MNNG for 10 days by gavage when they were new一born. The incidence of the three types of pathological lesions at the dose of 0.4mg MNNG per rat being 39%,50%and 100%respectively.Induction of gast ric adenocarcinoma is dose一dependent. The incidence of adenocarcinoma in male rats being significantly higher then that of female rats(P<0.02). 23 of 33(70%)induced cancers were found in the gastric antrum. By the use of DNA cotransfection technique and the assay of carcinogenicity in the Balb/c nude mice, it was also found that the DNA of 4of the 6 induced gastric carcinomas could transform NIH /3T3 cells into malignant cells,an indication that the induced cancer DNA contains transforming gene.
Chinese Journal of Pathology
Disease models,animal Adenocarcinoma