OBJECTIVE： To observe the Therapeutic effect of Man＇gan decoction plus compound glycyrrhizin in the treatment of chronic type B hepatitis. METHODS： 46 patients with chronic hepatitis B were randomly divided into treatment group and control group. The treatment group was treated with self-planned Man＇gan decoction for 6mo plus compound glycyrrhizin for 3mo; the control group received 6 months＇ conventional therapy-diammonium glycyrrhizinate, vitamin and amino acid compound injection, etc. RESULTS： At the end of treatment, the hepatic function and hepatic fibrosis index levels of the treatment group were superior to the control group（P〈0.05） and in which group 10 cases whose HBV-DNA turned negative and 9 cases whose HBeAg turned negative; there were 9 cases whose ALT recovered to normal level and HBV-DNA and HBeAg turned negative in this group, which were also superior to the control group（P〈0.05）. CONCLUSION：The therapy of Man＇gan decoction plus compound glycyrrhizin has a good therapeutic effect in the treatment of chronic type B hepatitis.