After IP administration of a bolus of large dose of 5-Fu, the drug concentration in peritoneal fluid,portal vein, hepatic vein were 288,13. 8,3. 7 times that of the femoral vein within 240 minutes respectively.The concentration of 5-Fu was highest in the liver, followed by the stomach,colon,lungs and kidneys in that order. A daily IP administration of 5-Fu was started on the following day after inoculating 5×10￣5 HCC cells into the peritoneal cavity of nude mice for 5 days.The result showed that all the control animals developed disseminated peritoneal growth of tumor, 2 of the nude mice in both 5-Fu 10mg/kg and 20mg/kg groups developed peritoneal growths, but no growth developed in the 5-Fu 30mg/kg group.That means that IP administration of 5-Fu is of advantage in preventing and treating tumor recurrence in the peritoneal cavity and hepatic metastasis after gastrointestinal tumor surgery.
Chinese Journal of Clinical Oncology
chemotherapy Pharmacokinetics Peritoneal cavity