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复方阿嗪米特治疗功能性消化不良、慢性胆囊炎、胆结石、肝硬化腹胀的疗效观察 预览 被引量:92

The effect of compound azintamide on abdominal fullness in patients with functional dyspepsia, chronic cholecystitis or liver cirrhosis
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摘要 目的观察复方阿嗪米特肠溶片对功能性消化不良、慢性胆囊炎、胆结石及肝硬化所致腹胀的疗效.方法将功能性消化不良、慢性胆囊炎、胆结石、肝硬化患者各20例纳入本研究.分别予以复方阿嗪米特肠溶片2粒,每日3次,疗程4周.观察治疗前后腹胀症状积分改变.功能性消化不良及慢性胆囊炎、胆结石患者治疗前后进行水负荷试验.结果复方阿嗪米特肠溶片可明显改善功能性消化不良、慢性胆囊炎、胆结石及肝硬化患者腹胀症状,治疗2周及4周腹胀症状积分均明显下降(P<0.01).治疗后功能性消化不良及慢性胆囊炎、胆结石患者最大饮水量明显增加(P<0.01),其对腹胀的总有效率为80%~85%.治疗过程中无不良反应发生.结论阿嗪米特肠溶片是治疗功能性消化不良,慢性胆囊炎、胆结石及肝硬化患者腹胀症状安全、有效的药物. Objective To investigate the effect of compound azintamide enteric-coated tablet on abdominal fullness in patients with functional dyspepsia, chronic cholecystitis with gallbladder stones, or liver cirrhosis. Methods Twenty patients with functional dyspepsia, 20 with chronic cholecystitis and gallbladder stones, and 20 with liver cirrhosis were enrolled in the study. Compound azintamide enteric- coated tablets were given 2 tablets 3 times daily for 4 weeks. The changes of symptom scores of abdominal fullness were investigated after the treatment. Water loading tests were carried out in patients with functional dyspepsia and chronic cholecystitis with gallbladder stones before and after the medication. Results Compound azintamide enteric-coated tablets greatly improved the symptom of abdominal fullness in each group of patients. Symptom scores were significantly decreased in 2 and 4 weeks (P〈0.01). The maximal water loading volume was significantly increased in patients with functional dyspepsia and chronic cholecystitis with gallbladder stones (P〈0.01). The total effective rate of compound azintamide for abdominal fullness was 80%-85%. There were no side effects in any of the patients during the treatment. Conclusion Compound azintamide enteric-coated tablet is effective in the management of abdominal fullness in patients with functional dyspepsia, chronic cholecystitis with gallbladder stones, and liver cirrhosis.
作者 邹多武 许国铭 苏暾 陆建萍 Zou DuoWu;Xu GuoMing;Su Tun;Liu JianPing
机构地区 上海
出处 《中华消化杂志》 CAS 北大核心 2005年第7期 421-424,共4页 Chinese Journal of Digestion
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  • 1Strid H, Norstrom M, Sjoberg J, et al. Impact of sex and psychological factors on the water loading test in functional dyspepsia. Scand J Gastroenterol, 2001,36:725-730. 被引量:1
  • 2Talley NJ. Drug treatment of functional dyspepsia. Scand J Gastroenterol, 1991,182 (Suppl):47-60. 被引量:1
  • 3Podda M, Zuin M, Dioguardi ML, et al. A combination of chenodeoxycholic acid and ursodeoxycholic acid is more effective than either alone in reducing biliary cholesterol saturation.Hepatology, 1982, 2:334-339. 被引量:1

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