Objective To investigate the effect of compound azintamide enteric-coated tablet on abdominal fullness in patients with functional dyspepsia, chronic cholecystitis with gallbladder stones, or liver cirrhosis. Methods Twenty patients with functional dyspepsia, 20 with chronic cholecystitis and gallbladder stones, and 20 with liver cirrhosis were enrolled in the study. Compound azintamide enteric- coated tablets were given 2 tablets 3 times daily for 4 weeks. The changes of symptom scores of abdominal fullness were investigated after the treatment. Water loading tests were carried out in patients with functional dyspepsia and chronic cholecystitis with gallbladder stones before and after the medication. Results Compound azintamide enteric-coated tablets greatly improved the symptom of abdominal fullness in each group of patients. Symptom scores were significantly decreased in 2 and 4 weeks （P〈0.01）. The maximal water loading volume was significantly increased in patients with functional dyspepsia and chronic cholecystitis with gallbladder stones （P〈0.01）. The total effective rate of compound azintamide for abdominal fullness was 80%-85%. There were no side effects in any of the patients during the treatment. Conclusion Compound azintamide enteric-coated tablet is effective in the management of abdominal fullness in patients with functional dyspepsia, chronic cholecystitis with gallbladder stones, and liver cirrhosis.
Chinese Journal of Digestion