期刊文献+

胸腺素β4与恶性肿瘤转移相关性研究进展 预览

Advance in relationship between thymosin beta 4 and tumor metastasis
在线阅读 下载PDF
分享 导出
摘要 胸腺素β4(Tβ4)是一种具有多重生物学功能的小分子多肽,它是G-actin隐蔽蛋白.Tβ4同G-actin按1:1比例结合成G-肌动蛋白Tμβ4复合体,维持细胞骨架的动态平衡.它在许多生理和病理活动中起重要作用:促进T细胞分化和成熟的作用;参与炎症过程,Tβ4对内皮细胞具有潜在趋化作用,通过刺激内皮细胞迁移促进血管生成、创伤愈合;在神经发育、细胞凋亡中发挥一定的作用.此外,Tβ4的异常表达与肿瘤转移关系密切,Tβ4可能通过诱导肿瘤血管生成、增强肿瘤细胞的运动和调节细胞的增殖等方面影响肿瘤的转移.对Tβ4进一步深入研究有助于肿瘤学者在治疗高转移肿瘤找到有效疗法,就Tβ4与肿瘤转移的相关性进行综述. Thymosin beta 4, a small peptide with more biologic functions, is known as a 4.9-kd polypeptide that interacts with G-actin and function as a major actin sequestering protein in cells by complexing with the monomeric G-actin in a 1 : 1 ratio. It plays an important role in physiological and pathological activities: It can promote T cell differentiation and maturation. Thymosin beta 4 may contribute to several physiological processes, including angiogenesis, wound healing, and regulation of inflammation. This peptide increases the rate of attachment and spreading of endothelial cells on matrix components. Thymosin beta 4 also plays a role in nerve developmeat and cell apotosis. Moreover, abnormal expression of the small peptide thymosin beta 4 is associated with the metastasis of tumor cells. It might induce tumor blood vessel formation, strengthen movement of the tumor cell and proliferation to influence metastasis of tumor. This paper reviews the advance in the relationship between thymosin beta 4 and the tumor metastasis.
作者 周瑞 袁宏银 熊斌 ZHOU Rui, YUAN Hong-yin, XIONG Bin( Department of Oneology, Zhongnan Hospital to Wuhan University, Wuhan 430071, P. R. China)
出处 《肿瘤防治杂志》 2005年第16期 1272-1276,共5页 China Journal of Cancer Prevention and Treatment
关键词 胸腺素 肿瘤转移 综述文献 thymosin neoplasm metastasis review literature
作者简介 周瑞,女,湖北广水人,硕士,主要从事消化道肿瘤的早期诊断与治疗的研究工作.TeL:86-27-87331314 E-mail:zhoulan110@163.net. 熊斌,男,湖北孝感人,博士,主任医师,主要从事恶性肿瘤转移的发生机制及防治的研究工作.Tel:86-27-67813152 E-mail:binxiong88@yahoo.com.
  • 相关文献

参考文献49

  • 1Clark E A, Golub T R, Lander E S, et al. Genomic analysis of me-tastasis reveals an essentialrole for Rhoc[J]. Nature, 2000,406(6795): 532 - 535. 被引量:1
  • 2Simenel C, Van Troys M, Vandekerckhove Ampe C, et al.Structural requirements for thymosin beta 4 in its contact with actin. An NMR-analysis of thymosin beta 4 mutants in solution and correlation with their biologicalactivity[J]. Eur J Biochem,2000,267 (12) : 3530 - 3538. 被引量:1
  • 3陈妍柯,杨辉,等.人胸腺肽β4基因的克隆表达及活性检测[J].生物化学与生物物理学报:英文版,2002,34(4):502-505. 被引量:7
  • 4Young J D, Lawrence A J, MacLean A G, et al. Thymosin beta 4sulfoxide is an anti-inflammatory agent generated by monocytes in the presence of glucocorticoids[J]. Nat Med, 1999,5(12):1424- 1427. 被引量:1
  • 5Gondo H, Kudo J, White J W, et al. Differential expression of the human thymosin beta 4 gene in lymphocytes, macrophages, and granulocytes[J]. J Immunol, 1987,139(11) :3840-3848. 被引量:1
  • 6Shahabuddin M, McKinley G, Potash M J, et al. Modulation of cellular gene expression of HIV type 1 infection as determined by subtractive hybridization cloning: Down regulation of thymosin beta 4 in vitro and in vivo[J]. AIDSRes Hum Retroviruses,1994, 10(11):1525-1530. 被引量:1
  • 7Sosne G, Chan C C, Thai K, et al. Thymosin beta 4 promotes corneal wound healing and modulates inflammatory mediators in vivo[J]. Exp Eye Res, 2001,72(5) :605-608. 被引量:1
  • 8Frohm M, Gunne H, Bergman AC,et al. Biochemical and antibacterial analysis of human wound and blister fluid[J]. Eur J Biochem, 1996, 237(1):86-92. 被引量:1
  • 9Huff T, Otto A M, Muller C S, et al. Thymosin beta4 is releaseedfrom human blood platelets andattached by factor X Ⅲ a (transglutaminase) to fibrin and collagen[J]. FASEB J, 2002,16(7):691-696. 被引量:1
  • 10Grant D S, Kinsella J L, Kibbey M C, et al. Matrigel inducesthymosin beta 4 gene in differrentiating endothelial cells[J]. JCell Sci, 1995,108(12) :3685-3694. 被引量:1

二级参考文献15

  • 1Low TL, Goldstein AL. Thymosins: Structure, function and therapeutic applications. Thymus, 1984, 6:27-42 被引量:1
  • 2Low TL, Goldstein AL. Chemical characterization of thymosin beta 4. J Biol Chem, 1982, 257(2) : 1000-1006 被引量:1
  • 3Erickson-Viitanen S, Ruggieri S, Natalini P, Horecker BL. Distribution of thyroxin beta 4 in vertebrate classes. Arch Biochem Biophys, 1983, 221(2): 570-576 被引量:1
  • 4Hall AK. Differential expression of thymosin genes in human tumors and in the developing human kidney. Int J Cancer, 1991, 48(5) : 672-677 被引量:1
  • 5Yamamoto T, Gotoh M, Kitajima M, Hirohashi S. Thymosin beta 4 expression is correlated with metastatic capacity of colorectal carcinornas. Biochem Biophys Res Commun, 1993, 193(2): 706-710 被引量:1
  • 6Clark EA, Golub TR, Lander ES, Hynes RO. Genomic analysis of metastasis reveals an essential role for RhoC. Nature, 2000, 406(6795) : 532-535 被引量:1
  • 7Condon MR, Hall AK. Expression of thyroxin beta-4 and related genes in developing human braim. J Mol Neurosci, 1992, 3(3):165-170 被引量:1
  • 8Roth L W, Borman P, Bonnet A, Reinhard E. Beta-thymosin is required for axonal tract formation in developing zebrafish brain.Development, 1999, 126:1365-1374 被引量:1
  • 9Bonnet D, Lemoine FM, Frobert Y, Bonnet ML, Baillou C, Najman A, Guigon M. Thymosin beta 4 inhibitor for normal hematopoietic progenitor cells. Exp Hematol, 1996, 24( 7 ):776-782 被引量:1
  • 10Safer D. The interaction of actin with thymosin beta 4. J Muscle Res Cell Motil, 1992, 13(3) : 269-271 被引量:1

共引文献6

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部 意见反馈