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缬沙坦对高血压病患者左室肥厚和胰岛素抵抗的影响 预览 被引量:3

Effects of Valsartan in insulin resistance and left ventricular hypertrophy in essential hypertension
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摘要 目的探讨原发性高血压患者经缬沙坦治疗后其血胰岛素抵抗及左室肥厚的变化.方法对56例高血压病患者和56例健康对照组测定空腹及餐后2h血糖、胰岛素、C肽值,计算胰岛素敏感性指数,进行超声心动图检查.高血压病患者接受缬沙坦降压治疗21周后,复查上述指标并与用药前进行对比研究.结果缬沙坦对高血压病患者能够显著降低血压,提高胰岛素敏感指数(P<0.01),室间隔厚度、左心室后壁厚度、左室心肌重量及左室重量指数较治疗前显著改善(P<0.01).结论胰岛素抵抗可能是高血压病患者合并左室肥厚的诱发因素之一.缬沙坦在降压的同时,具有改善其胰岛素抵抗和左心室肥厚的作用. Objective To investigate changes of valsartan on insulin resistance and left ventricular hypertrophy in patients with essential hypertension. Methods The concentrations of fasting blood glucose, serum insulin, and c peptide(c-p) were measured in 56 hypertensive patients and 56 control healthy subjects. Valsartan was used to treat hypertension for 21 weeks, Recheck the above Laboratory tests after treatment. The insulin sensitivity index(ISI) of each group was calculated and compared. Echocardiography was examined before and after 21 weeks of treatment. Results After 21 weeks treatment of valsartan, blood pressure was reduced significantly (P〈 0.01),ISI was increased(P〈0.01).Interventricular septum thickness and left ventricular posterior wall thickness,left ventricular mass and index of left ventricular mass were improved significantly (P〈0.01). Conclusion Blood pressure were decreased significantly. Insulin resistance and left ventricular hypertrophy were improved by the treatment of valsartan in patients with essential hypertension.
作者 聂建平 付金国 赵勇 蔡新根 郭治彬 Nie Jianping, Fu Jinguo, Zhao Yong ,et al( The Pepole's Hospital of Fengcheng city, Jiangxi,331100,China).
出处 《江西医药》 CAS 2005年第10期 596-598,共3页 Jiangxi Medical Journal
关键词 高血压病 缬沙坦 胰岛素抵抗 左室肥厚 Valsartan Insulin Resistance Left Ventricular Hypertrophy
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  • 1Holwerda NJ,Fogari R,Angeli P, et al. Valsartan,a new angiotension Ⅱantagonist for the treatment of essential hypertension.Efficacy and safty compared to placebo and enalapril.J Hypertens,1996,14:1147. 被引量:1
  • 2Resnik LM.Hypertension and peripheral insulin resistance. Am J Hypertens,1990,3:373. 被引量:1
  • 3Kamide K, Nagano M,Nakano N,et al. Insulin resistance and cardiovascular complication in patients with essential hypertension. Am JHyperten, 1996,9:1165. 被引量:1
  • 4Devereux RB, Reichech N.Echocardiographic determination of left ventricular mass in man. Anatomic validation of method. Circulation,1977,55:613. 被引量:1
  • 5李光伟,Step.,L.检测人群胰岛素敏感性的一项新指数[J].中华内科杂志,1993,32(10):656-660. 被引量:2052
  • 6Yu HW,Dong QJ,Kai Y,et al.Effects of felodipine ,eanalapril,Losartan and terazosin on insulin resistance in patients with essential hypertension.Internat J Cardiov Med,2001,3(2):115. 被引量:1

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  • 1顾勇,赖凌云.肾素-血管紧张素系统在糖尿病肾病研究中的新进展[J].中华肾脏病杂志,2004,20(3):221-223. 被引量:43
  • 2Zhang L, Wang F, Wang L, et al. Prevalence of chronic kidney dis- ease in China: a cross,sectional survey [J]. Lancet, 2012, 379 (9818):815 - 822. 被引量:1
  • 3Chen G, McAlister FA, Walker RL, et al. Cardiovascular outcomes in framingham participants with diabetes: the importance of blood pressure[J]. Hypertension,2011, 57 (5):891 - 897. 被引量:1
  • 4Genuth S. The UKPDS and its global impact[J]. Diabet Med, 2008, 25(Suppl 2):57-62. 被引量:1
  • 5Bangalore S, Kumar S, Lobach I, et al. Blood pressure targets in subjects with type 2 diabetes mellitus/impaired fasting glucose: ob- servations from traditional and bayesian random-effects meta- analyses of randomized trials [J]. Circulation, 2011,123 (24):2799 2I0. 被引量:1
  • 6Redon J, Mancia G, Sleight P, et al. Safety and efficacy of low blood pressures among patients with diabetes .Subgroup analyses from the ONTARGET (Ongoing telmisartan alone and in combina- tion with Ramipfil Global Endpoint Trial)[J]. J Am Coil cardiol, 2012, 59(1): 74-83. 被引量:1
  • 7Aronow WS, F]eg JL, Pepine CJ, et al. ACCF/AHA 2011 expert consensus document on hypertension in the elderly: a report of the American college of cardiology foundation task force on clinical expert consensus documents. Developed in collaboration with the American academy d neurology, American geriatrics society, American society for preventive cardiology, American society of hypertension, American society of nephrology, association of black cardiologists, and European society of hypertension [J]. J Am Coll Cardiol, 2011, 57(20):2037-2114. 被引量:1
  • 8Hackam DG, Khan NA, Hemmelgam BR, et al. The 2010 Canadian Hypertension Education Program recommendations for the manage- ment of hypertension: part 2-therapy [J]. Can J Cardiol, 2010, 26 (5):249-258. 被引量:1
  • 9Mancia G, De BG, Dominiezak A, et al. 2007 Guidelines for the management of arterial hypertension: The task force for the man-agement of arterial hypertension of the European Society of Hyper- tension (ESH) and of the European Society of Cardiology (ESC)[J]. J Hypertens, 2007, 25(6):1105-1187. 被引量:1
  • 10Youssouf Radjab, Souad Aboudrar, Fatima Zahra Milouk, et al. Cardiovascular autonomic response to amlodipine in primary hyper- tension[J]. ISRN Cardiol, 2012, 2012: 832183. 被引量:1

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