Tacrolimus is a macrolide immunosupressant. The mechanism of its action is similar to that of cy-closporine. Systemic tacrolimus is mostly used in the prevention of rejection after organ transplantation and in the treatment of immune diseases. Since the molecular weight of tacrolimus is low, it can penetrate the epidermal barrier, which is different from cyclosporine. In order to avoid systemic side effects, topical agents of tacrolimus have been manufactured for the treatment of immune and inflammatory dermatoses. This article reviews the topical use of tacrolimus ointment in the treatment of skin diseases.
International Journal of Dermatology and Venereology