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局部外用他克莫司治疗皮肤病 预览 被引量:14

Topical Application of Tacrolimus in Skin Diseases
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摘要 他克莫司是一种大环内酯类免疫抑制剂,其作用机制与环孢素相似,全身应用主要用于预防异体器官移植的排斥反应以及治疗免疫性疾病。与环孢素不同的是,由于它相对分子质量相对较小,可以穿透表皮屏障,为避免全身不良反应的发生,可制成外用制剂治疗各种免疫性和炎性皮肤病。 Tacrolimus is a macrolide immunosupressant. The mechanism of its action is similar to that of cy-closporine. Systemic tacrolimus is mostly used in the prevention of rejection after organ transplantation and in the treatment of immune diseases. Since the molecular weight of tacrolimus is low, it can penetrate the epidermal barrier, which is different from cyclosporine. In order to avoid systemic side effects, topical agents of tacrolimus have been manufactured for the treatment of immune and inflammatory dermatoses. This article reviews the topical use of tacrolimus ointment in the treatment of skin diseases.
作者 顾有守 GU You-shou. (Guangdong Provincial Centers for Skin Diseases and STIs Control and Prevention, Guanzhou 510500, China)
出处 《国际皮肤性病学杂志》 2006年第1期 59-62,共4页 International Journal of Dermatology and Venereology
关键词 他克莫司 皮肤疾病 治疗 Tacrolimus Skin diseases Therapy
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参考文献22

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