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抗核小体抗体测定在系统性红斑狼疮中的意义 预览 被引量:10

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摘要 目的:评价抗核小体抗体(AnuA)在系统性红斑狼疮(SLE)中的意义。方法:采用放射免疫法检测50例SLE患者、20例其他结缔组织病患者及25例健康人血清中抗双链DNA(dsDNA)抗体,用德国IMTEC公司抗核抗体谱线性印迹法检测AnuA、抗SmD.、抗组蛋白抗体。结果:AnuA、抗组蛋白、抗SmDl、抗dsDNA抗体在SLE中的阳性率分别为72.0%、32.0%、82.0%、44.0%。特异性分别为90.0%、85.0%、85.0%、100%,诊断效率分别为77.1%、48.6%、82.9%、60.0%。C3、C4在SLE中AnuA阳性组和AnuA阴性组间差异有显著性,免疫球蛋白在SLE中AnuA阳性组和AnuA阴性组间差异无显著性。结论:AnuA与SLE的活动性相关;AnuA在SLE中的敏感性、特异性和诊断效率高,尤其适用于诊断抗组蛋白、抗dsDNA抗体阴性的SLE。
出处 《实用医学杂志》 CAS 2006年第3期 338-339,共2页 The Journal of Practical Medicine
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参考文献7

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