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外周血CD5^+B细胞变化与Graves病病情活动性相关 被引量:11

Alteration in peripheral blood CD5^+ B cells is associated with disease activity in Graves' disease
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摘要 应用流式细胞术检测43例Graves病(GD)患者药物治疗前后外周血CD5^+B细胞。与正常对照者比较,GD患者外周血中CD5^+B细胞明显升高[(17.0+5.1)%vs(39.5+12.4)%]。GD患者经治疗后,CD5^+B细胞明显下降(P〈0.01)。GD患者的CD5^+B细胞水平与FT4、FT3、TT4、TT3均呈正相关。 Peripheral blood CD5^+B cell was detected by flow cytometry in patients with Graves' disease (GD) before and after treatment. As compared with normal controls, peripheral blood CD5^+B cells in a group of 43 patients with GD showed a significant increase in number [ ( 17.0 + 5.1 ) % vs (39.5 + 12.4) %, P 〈 0.01 ]. After treatment, peripheral blood CD; B cells showed a significant decrease in patients with GD ( P 〈 0.01 ). There were positive correlations between numbers of peripheral bloed CD; B cells and serum levels of FT4 ,FT3 ,TT4 ,TT3 in the patients with GD.
作者 斯徐伟 詹乾钢 朱麒钱 官莉莉 俞钟明 楼大钧 金华伟 马静波 叶飞 SI Xu- wei, ZHAN Qian-gang, ZHU Qi-qian, GUAN Li-li, YU Zhong-ming, LOU Da-jun, JIN Hua-wei, MA Jing-bo, YE Fei( Shaoxing People's Hospital ,Shaoxing, Zhejiang 312000)
出处 《中华内分泌代谢杂志》 CAS CSCD 北大核心 2006年第2期 121-122,共2页 Chinese Journal of Endocrinology and Metabolism
关键词 格雷夫斯病 B淋巴细胞 抗原 CD5 流式细胞术 Graves' disease B-lymphocytes Antigens, CD5 Flow cytometry
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