期刊文献+

芍药苷对小鼠学习记忆能力的影响 预览 被引量:23

Effects of paeoniflorin on learning and memory ability in mice
在线阅读 下载PDF
收藏 分享 导出
摘要 目的:观察芍药苷对东莨菪碱致小鼠记忆形成障碍、亚硝酸钠致记忆巩固障碍和乙醇致记忆再现障碍的影响.方法:采用小鼠跳台法和Y-型迷宫法.结果:芍药苷7.5、15、30mg/kg iv 3日对小鼠学习记忆功能有明显的促进作用,对东莨菪碱致小鼠记忆形成障碍、亚硝酸钠致记忆巩固障碍和乙醇致记忆再现障碍有明显的改善作用,且呈一定的剂量依赖关系.结论:芍药苷对东莨菪碱、亚硝酸钠和乙醇致小鼠记忆获得、巩固及再现障碍均有不同程度的改善作用. To study the effects of paeoniflorin on learning and memory abilities. Methods: the step-down test and Y-maze test were adopted. Results: The results indicated that paeoniflorin (7.5,15,30mg/kg, iv x 3d) dose-dependently improved the impairment of memory acquisition, memory consolidation and memory retrieval induced by scopolamine, NaNO2 and alcohol in mice. Conclusion: Paeoniflorin can improve the impairment of memory acquisition, memory consolidation and memory retrieval induced by scopolamine, NaNO2 and alcohol in mice.
作者 孙蓉 吕丽莉 刘国卿 Sun Rong, Lv Lili , Liu Guoqing (1 Pharmacology Department of China Pharmaceutical University, Nanjing 210009;2 Shandong Academy of TCM, Jinan 250014)
出处 《中药药理与临床》 CAS CSCD 北大核心 2006年第1期 23-25,共3页 Pharmacology and Clinics of Chinese Materia Medica
关键词 芍药苷 学习记忆 跳台法 迷宫法 paeoniflorin learning and memory ability step-down test Y-maze test
  • 相关文献

参考文献6

  • 1Bartus RT,Dean RL,Beer B,et al.The cholinergic hypothesis of geriatric memory dysfunction.Science,1982; 217:408 被引量:1
  • 2Eagger SA,Levy R,Sahakian B J,et al.Tacrine in Alzheimer's Disease.Lancet,1991; 337:989 ~992 被引量:1
  • 3张艳,张鹤云,李卫平,祁岩超,明亮,马传庚,徐叔云,.安吉复的促智作用研究[J].中国药理学通报,1995,11(3):233-236. 被引量:22
  • 4Bymster FP,Health I,Hendrix JC,et al.Comparative behavioral and neurochemical activities of cholinergic antagonist in rats.J Pharmacol Exp Ther,1993; 267:16 被引量:1
  • 5Speiser Z,Amitzi-Zonder J,Ashkenazi R,et al.Central catecholaminergic dysfunction and behavioral disorders following hypoxia.Behav Brain Res,1990; 37:19 被引量:1
  • 6Gerhard F.Chronic central nervous systemtoxicity of alchohol.Ann Rev Pharmacol Toxical,1973; 13:217 ~20 被引量:1

二级参考文献1

  • 1张均田.近年国内关于学习与记忆药理学研究概况[J]药学学报,1986(08). 被引量:1

共引文献21

同被引文献298

引证文献23

二级引证文献331

投稿分析

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部 意见反馈