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三七醇提液对恶性肿瘤肝转移的干预作用 预览 被引量:21

Effects of ethanol extracts of Panax notoginseng on liver metastasis of B16 melanoma grafted in mice
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摘要 目的:观察三七醇提液对恶性肿瘤肝转移的干预作用。方法:建立肿瘤肝转移模型,观察不同剂量三七醇提液对荷瘤肝转移小鼠生存质量、肿瘤生长和肝转移的影响。结果:三七醇提液可以改善荷瘤肝转移小鼠的全身情况,并具有明显的抑瘤和抗肝转移作用,这种作用又以三七醇提液中、低剂量组更为明显。结论:三七醇提液可改善荷瘤鼠全身情况,并具有抑瘤、抗转移的作用。 Objective: To observe the effects of ethanol extracts of Panax notoginseng on the tumor and the liver metastasis in experimental mice grafted with B16 melanoma. Methods: B16 melanoma was transplanted in the spleen of C57BL/6 mice. The effects of different doses of ethanol extracts of Panax notoginseng on the inhibition rate of spleen tumors and the liver metastasis were observed respectively. Results: The high-, medium-, and low-doses of the extracts and the interferon-α (IFN-α) can improve the quality of life of the experimental mice. The weights of spleen tumor were lower in the low- and medium-dose extracts-treated groups and the IFN-α-treated group than that in the normal saline (NS)-treated group (P〈0.05 or P〈0.01). The liver metastasis was less in the low- and medium-dose extracts-treated groups and the IFN-α-treated group than that in the NS-treated group (P〈0.01). Conclusion: The ethanol extracts of Panax notoginseng can improve the quality of life of the experimental mice and inhibit the growth of tumor and the liver metastasis.
作者 陈培丰 刘鲁明 陈震 林胜友 宋伟祥 徐颖扉 Pei-Feng CHEN, Lu-Ming LIU, Zhen CHEN, Sheng-You LIN, Wei-Xiang SONG, Ying-Fei XU (1. Department of Oncology, First Hospital, Zhejiang University of Traditional Chinese Medicine, Hangzhou, Zhejiang Province 310006, China; 2. Department of Integrated Traditional Chinese and Western Medicine, Cancer Hospital, Fudan University, Shanghai 200032, China)
出处 《中西医结合学报》 CAS 2006年第5期 500-503,共4页 Journal of Chinese Integrative Medicine
关键词 三七 肝转移 肿瘤 小鼠 Panax notoginseng liver metastasis tumor mice
作者简介 Correspondence to: Pei-Feng CHEN, Associate Professor. E-mail:cpf12345@163.com
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