期刊文献+

喉咽鳞癌患者外周血T淋巴细胞亚群和NK细胞活性分析 预览 被引量:9

Analysis of Serum T-lymphocyte Subsets and NK Cell Activity in Patients with Hypopharyngeal Squamous Cell Carcinoma
在线阅读 免费下载
收藏 分享 导出
摘要 背景与目的:T淋巴细胞亚群及NK细胞是主要的细胞免疫形式,通过对两者的研究可以了解细胞免疫在肿瘤发生、发展的作用、喉咽鳞癌患者可能存在一定程度的细胞免疫缺陷。本研究是通过检测外周血T淋巴细胞亚群及NK细胞活性,了解喉咽鳞癌患者的细胞免疫功能。方法:用流式细胞仪对78例喉咽鳞癌患者的外周血进行T淋巴细胞亚群及NK细胞活性的检测。并取20例非肿瘤患者的外周血作为对照组。结果:喉咽鳞癌患者组较非肿瘤患者组CD4淋巴亚群、CD4/CD8比值下降,CD8淋巴亚群升高:NK细胞活性下降.T3~4组较TI~2组、N^+组较N0组都有CD4淋巴亚群、CD4/CD8比值下降;NK细胞活性下降。中低分化组CD4淋巴亚群、CD4/CD8比值下降(均P〈0.05)。结论:喉咽鳞癌患者CD4T淋巴细胞亚群及NK细胞活性受到抑制,细胞免疫功能降低:检查外周血T淋巴细胞亚群及NK细胞活性有助于喉咽鳞癌患者的细胞免疫功能监测。 BACKGROUND & OBJECTIVE: T-lymphocyte subsets and NK cell are the major forms of cellular immunity. Study of these 2 types of cells may lead to the better understanding of the function of cellular immunity in the onset and development of carcinoma. To a certain degree, there may be cellular immunodeficiency existing in patients with hypopharyngeal squamous cell carcinoma. This study was to investigate the cellular immunity function in these patients. METHODS: T-lymphocyte subsets and NK activity were determined by flow cytometry in 78 patients with hypopharyngeal squamous cell carcinoma. Blood samples of 20 non-tumor patients were used as control. RESULTS- The levels of CD4 lymphocyte subsets, CD4/CD8 ratio, and NK activity were lower in carcinoma group than in control group, but CD8 lymphocyte level was higher in carcinoma group. The levels of CD4 lymphocyte subsets, CD4/CD8 ratio, and NK activity were lower in T3-4 group than in T1-2 group, and lower in N+ group than in NO group. The levels of CD4 lymphocyte subsets and CD4/CD8 ratio were decreased in the carcinoma with moderate or low differentiation (P〈0.05). CONCLUSIONS.. T- lymphocyte subsets and NK activity are inhibited, and the cellular immunology is suppressed in the patients with hypopharyngeal squamous cell carcinoma. Analyzing T-lymphocyte subsets and NK activity would be helpful to evaluate the cellular immunologic condition of these patients.
作者 陈文宽 宋明 陈福进 郭朱明 何丽容 严苏丽 CHEN Wen-Kuan, SONG Ming,CHEN Fu-Jin, GUO Zhu-Ming, HE Li-Rong, YAN Su-Li(1. State Key Laboratory of Oncology in South China, Guangzhou , Guangdong , 510060, P. R. China 2. Department of Head and Neck Surge ry , Cancer Center, Sun Yat-sen University, Guangzhou , Guangdong , 510060, P. R. China 3. Clinical Ltdoratory, Cancer Center, Sun Yat-sen University, Guangzhou , Guangdong , 510060, P. R. China)
出处 《癌症:英文版》 SCIE CAS CSCD 北大核心 2006年第10期 1300-1302,共3页 Chinese Journal of Cancer
关键词 喉咽肿瘤 T淋巴细胞亚群 NK细胞 流式细胞分析 Hypopharyngeal neoplasm T-lymphocyte subsets NK cells Flow cytometry
作者简介 通讯作者:陈文宽 Tel:86—20—87343300 E—mail:chenwenkuan@163.com
  • 相关文献

参考文献6

二级参考文献13

共引文献31

同被引文献92

引证文献9

二级引证文献52

投稿分析

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部 意见反馈