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消化系统恶性肿瘤患者止凝血异常的研究 预览 被引量:7

The Study of Heamostatic Alterations in Patients with Gastrointestinal Cancer
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摘要 目的通过测定血浆止凝血指标及细胞因子IL-6、TNFα的浓度变化,初步探讨消化系统恶性肿瘤患者止凝血异常的原因。方法测定42例消化系统恶性肿瘤患者TF、凝血因子Ⅱ、Ⅴ、Ⅶ、Ⅷ、Ⅸ、Ⅹ、Ⅺ活性以及Fbg、D二聚体、tPA、IL-6、TNFα血浆浓度,并与正常对照进行比较。结果TF、Fbg、D二聚体、tPA血浆浓度均高于正常对照(P〈0.05或P〈0.01)。结论消化系统恶性肿瘤患者在确诊时已存在止凝血指标异常,机体凝血、纤溶系统均处于激活状态。 Objective To investigate the clinical significance of the changes of plasma haemostatic markers, interleukin-6 (IL-6) and tumor necrosis factor-α (TNFα) concentration in patients with gastrointestinal cancer. Methods In 42 patients with gastrointestinal cancer, we evaluated markers of heamastatic function, including levels of tissue factor, fibrinogen and its degradation products D-dimer, tissue plasminogen activator, as well as activities of coagulation factors Ⅱ , Ⅴ, Ⅶ, Ⅷ, Ⅸ, Ⅹ, Ⅺ. The concentrations of IL-6 and TNFα were also detected. A group of healthy volunteers was teken as controls. Results It was found that the levels of tissue factor, fibrinogen, D-dimer and tissue plasminogen activator significantly increased in the patients (P 〈0.05 or P 〈0.01 ). Conclusion The hasmostasis disorders were existed in patients with gastrointestinal cancer when the diagnosis was just made.
作者 姚一芸 胡钧培 叶为德 YAO Yi-yun, HU Jun-pei, YE Wei-de ( Department of Hematology, Shanghai Ninth People's Hospital, Medical College, Shanghai Jiao Tong University, Shanghai 200011 ,China )
出处 《血栓与止血学》 2006年第6期 254-255,261,共3页 Chinese Journal of Thrombosis and Hemostasis
关键词 消化系统恶性肿瘤 止凝血功能 IL-6 TNFΑ Gastrointestinal Cancer Haemostatic function Interleukin-6 Tumor necrosis factor-α
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  • 1李家增.止血异常与恶性肿瘤[J].血栓与止血学,2006,12(2):88-89. 被引量:29
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