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脑血管血流动力学积分对高血压患者卒中相对危险度的评估 预览 被引量:18

Evaluation of the relative risk of stroke in patients with hypertension using cerebrovascular hemo- dynamic accumulative scores
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摘要 目的以脑血管血流动力学综合评估指标,评估高血压患者卒中的相对危险度(RR)。方法选择卒中危险因素研究队列人群中年龄≥40岁的高血压患者7371例,对其危险因素基线调查、脑血管血流动力学指标(CVHI)检测、卒中随访资料进行分析,以CVHI积分值评估高血压患者的卒中危险度。结果单因素分析显示,与高血压患者卒中发病有显著性联系的危险因素分别是CVHI积分值降低、心脏病、吸烟和饮酒,其RR分别为4.93(95%CI:3.26~7.45)、1.90(95%CI:1.36~2.66)、1、99(95%CI:1.42~2.79)和1.73(95%CI:1.19~2.53)。多因素分析结果显示,被筛选进入Cox回归方程的变量分别为CVHI积分、年龄、性别、吸烟、卒中家族史和收缩压水平,其中CVHI积分的RR值(3.518,95%CI:2.119~5.841)最高。剂量反应关系分析显示,高血压患者CVHI积分值75分以下每降低15分,卒中的RR值分别为2.85、4.43、4.54、5.40、9.88。结论高血压患者卒中风险与血流动力学损害密切相关,CVHI积分可定量评估卒中的相对危险度。 Objective To evaluate the relative risk (RR) of stroke in patients with hypertension using synthetic indexes of cerebrovascular hemodynamics, Methods A total of 7 371 patients with hypertension aged ≥40 years were selected from a population-based cohort study of the risk factors for stroke. Their baseline investigation of risk factors, cerebrovascular hemodynamic index (CVHI) determination and follow up data of stroke were analyzed. The RR of stroke in patients with hypertension was evaluated by CVHI scores. Results Univariate analysis indicated that hypertension complicated other risk factors had significant statistical association with the onset of stroke, they were the decrease of hemodynamic scores, heart disease, cigarette smoking and alcohol consumption, the RR were 4.93 (95% CI, 3.26-7.45 ) , 1.90 (95% CI, 1.36-2. 66), 1.99 (95% CI, 1.42-2.79) and 1.73 (95% CI, 1.19-2. 53) respectively. Multivariate analysis indicated that the variates selected for entering Cox regression equation were hemodynamic scores, age, sex, cigarette smoking, family history of stroke and systolic blood pressure, among them the RR of hemodynamic scores was the highest. The analysis of dose response relation indicated that if the hemodynamic scores in patients with hypertension were lower than 75 points with every 15-point reduction, the RR of stroke were 2. 85, 4.43, 4. 54, 5.40, and 9.88, respectively. Conclusion The risk of stroke in patients with hypertension is closely associated with the hemodynamic injury, and the hemodynamic scores may quantificationally evaluate the relative risk of stroke.
作者 黄久仪 王桂清 郭吉平 曹奕丰 王艳 杨永举 俞学海 HUANG Jiu-yi, WANG Gui-qing, GUO Ji-ping, CAO Yi-feng, WANG Yan, YANG Yong-ju, YU Xue-hai. (Shanghai Institute of Cerebrovascular Diseases, Shanghai 201318, China)
出处 《中国脑血管病杂志》 CAS 2006年第12期 537-541,576,共6页 Chinese Journal of Cerebrovascular Diseases
基金 国家自然科学基金资助项目(39370612) 国家“十五”滚动基金资助项目(2004BA703B12)
关键词 高血压 中风 血液动力学过程 队列研究 Hypertension Stroke Hemodynamic processes Cohort study
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参考文献14

  • 1[1]Asia Pacific Cohort Studies Collaboration.Joint effects of systolic blood pressure and serum cholesterol on cardiovascular disease in the Asia Pacific region.Circulation,2005,112:3384-3390. 被引量:1
  • 2[2]Psaty BM,Furberg CD,Kuller LH,et al.Association between blood pressure level and the risk of myocardial infarction,stroke,and total mortality:the cardiovascular health study.Arch Intern Med,2001,161:1183-1192. 被引量:1
  • 3[3]Derdeyn CP,Grubb RL Jr,Powers WJ.Indications for cerebral revascularization for patients with atherosclerotic carotid occlusion.Skull Base,2005,15:7-14. 被引量:1
  • 4黄久仪,王桂清,沈凤英,曹奕丰,王艳,郭佐,杨永举,樊舜英,徐晓斌,冯春红,田文生.脑血管血液动力学积分与脑卒中风险的队列研究[J].中华流行病学杂志,2003,24(2):89-93. 被引量:93
  • 5周北凡.我国成人体重指数和腰围对相关疾病危险因素异常的预测价值:适宜体重指数和腰围切点的研究[J].中华流行病学杂志,2002,23(1):5-10. 被引量:2606
  • 6黄久仪,郭佐,等.脑血管血液动力学检测预警卒中的筛检试验评价[J].中华流行病学杂志,2002,23(5):383-386. 被引量:73
  • 7[8]MachMahon S,Peto R,Cutler J,et al.Blood pressure,stroke,and coronary heart disease,part 1:prolonged difference in blood pressure:prospective observational studies corrected for the regression dilution bias.Lancet,1990,335:765-774. 被引量:1
  • 8[9]Qureshi AI,Suri MF,Mohammad Y,et al.Isolated and borderline isolated systolic hypertension relative to longterm risk and type of stroke:a 20-year follow-up of the national health and nutrition survey.Stroke,2002,33:2781-2788. 被引量:1
  • 9[10]Lu X,Zhao JB,Wang GR,et al.Remodeling of the zerostress state of femoral arteries in response to flow overload.Am J Physiol Heart Circ Physiol,2001,280:1547-1559. 被引量:1
  • 10[11]Kawashima S,Yokoyama M.Dysfunction of endothelial nitric oxide synthase and atherosclerosis.Arterioscler Thromb Vasc Biol,2004,24:998-1005. 被引量:1

二级参考文献28

  • 1张红叶,杨军,周北凡,武阳丰,李莹,陶寿淇,.我国十组人群脑卒中危险因素的前瞻性研究[J].中国慢性病预防与控制,1996,4(4):150-152. 被引量:86
  • 2孙继虎 汪洋 等.血管内皮细胞的培养和形态学观察[J].解剖学杂志,1996,19:221-221. 被引量:1
  • 3王桂清 郭佐 樊舜英 柳兆荣 陈君楷 吴望一.从正常到中风脑血管血流动力学的变化规律[A].柳兆荣,陈君楷,吴望一.生物力学新近展[M].成都:成都科学技术大学出版社,1996.255-8. 被引量:5
  • 4郭佐 王桂清 等.脑血管血液动力学参数的主成分分析和脑血管功能的综合评估.生物力学新近展[M].成都科技大学出版社,1996.260-264. 被引量:2
  • 5王桂清 郭佐 等.从正常到中风脑血管血液动力学的变化规律.生物力学新进展[M].成都科技大学出版社,1996.255-258. 被引量:3
  • 6孙长生 李良寿.筛检与诊断试验的评价.临床科研原理与方法[M].西安:陕西科技出版社,2000.179-195. 被引量:2
  • 7曹家琪 连志浩 等.队列(群组)研究.流行病学,第2版,第1卷[M].北京:人民卫生出版社,1995.190-206. 被引量:2
  • 8Garcia-Cardena G, Comander JI, Blackman BR, et al. Mechanosensitive Endothelial Gene Expression Profiles: Scripts For the Role of Hemodynamics in Atherogenesis[J] ? Ann N Y Acad Sci, 2001, 947: 1-6. 被引量:1
  • 9Malek AM, Alper SL, Izumo S. Hemodynamic Shear Stress and Its Role in Atherosclerosis[J]. JAMA, 1999, 282:2035-2042. 被引量:1
  • 10Chiu JJ, Chen LJ, Chen CN, et al. A Model for Studying the Effect of Shear Stress on Interactions between Vascular Endothelial Cells and Smooth Muscle Cells[J]. J Biomech, 2004, 37:531-539. 被引量:1

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