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心力衰竭患者血清血管内皮生长因子和C-反应蛋白的变化及意义 预览 被引量:3

Changes and clinical significance of serum vascular endothelial growth factor and C-reactionpretein in patients with heart failure
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摘要 目的检测心力衰竭(HF)患者血清血管内皮生氏因子(VEGF)和G反应蛋白(CRP)的水平,探讨VEGF在HF发生和发展过程中的作用。方法选取HF患者100例,其中男性53例,女性47例。将慢性HF患者按NYHA标准进行心功能分级,心功能Ⅱ级为Ⅱ组(37例),心功能Ⅲ~Ⅳ级为Ⅲ组(32例),急性HF患者为Ⅳ组(31例)。测定VEGF及CRP水平,比较各组间VEGF、CRP的变化,并与正常对照组(Ⅰ组,n=35)比较,同时分析VEGF和CRP之间的相关性。分析原发性高血压、高胆固醇血症、糖尿病、及稳定型心绞痛对HF患者VEGF水平的影响。结果(1)Ⅱ~Ⅳ组的VEGF和CRP水平均显著高于Ⅰ组(P均〈0.05)。(2)Ⅳ组VEGF水平显著高于Ⅲ组和Ⅱ组(P均〈0.05);Ⅱ组和Ⅲ组VEGF水平无显著差异(P2〉0.05);Ⅲ组CRP水平显著高于Ⅱ组(P〈0.05);Ⅳ组和Ⅲ组CRP水平无显著差异(P2〉0.05)。(3)HF患者血清VEGF与CRP无相关性(r=0.1786,P〉0.05)。(4)原发性高血压HF组和血压正常HF组VEGF无显著差异(P〉0.05)。高胆固醇HF组和胆固醇正常HF组比较、糖尿病HF组和非糖尿病HF组比较、稳定型心绞痛HF组和不合并心绞痛HF组比较VEGF均无显著差异(P均〉0.05)。结论HF患者VEGF及CRP水平显著升高。急性HF组高于慢性HF组,VEGF及CRP水平均随着HF程度的加重而升高,原发性高血压、高胆固醇血症、糖尿病、及稳定型心绞痛对HF患者血清VEGF水平可能无明显影响。 Objective To observe the change and ito clinical significance of serum vascular endothelial growth (VEGF)and C-reaction protein(CRP) in patients with heart failure (HF) Methods This study was carried out in 100 patients admitted to hospital with the primary diagmosis of HF. Of these, 37 were chronic HF with NYHA function class Ⅱ (group Ⅱ ), 32 were chronic HF with NYHA function class Ⅲ or Ⅳ (group Ⅲ) ,31 patients were acute HF (group Ⅳ),35 healthy hospital staffs were recruited as normal controls ( group Ⅰ). Each patient was measured the serum levels of VEGF and CRP. Comparing the changes of analyzing the effect of the VEGF and CRP levels among those groups, analyzing the correlation of VEGF and CRP. hypertention, hypercholesteremia, diabets and stable angina pectoris contributed to the variation of on VEGF level. Results 1. Comparing with group Ⅰ, the serum levels of VEGF and CRP were significantly higher in group Ⅱ - Ⅳ ( P〈 0.05 ). Group Ⅳ has significantly higher VEGF level than group Ⅱ and Ⅲ ( P〈 0.05 ). there was no significant difference in VEGF level between group Ⅱ and group Ⅲ (P〉0.05). 2. Group Ⅲ has higher CRP level than group Ⅱ ( P〈 0.05 ). There was no significant difference between group Ⅲ and group Ⅳ regarding of the CRP level( P 〉 0.05 ) . 3. The data showed no association between VEGF and CRP. ( r = 0.1786; P 〉 0.05 ). 4. None of the diseases (hypertention, hypercholesteremia, diabets and stable angina pectoris) contributed to the variation of VEGF level in this study. Conclusions The levels of serum VEGF and CRP increase significantly in HF patients, the level of serum VEGF is higher in patients with acute HF than chronic HF. The levels of serum VEGF and CRP increase accompany with the deterioration of HF, Serum VEGF level is not influenced by hypertention, hypercholesteremia, diabets and stable angina pectons.
作者 初红霞 陶志刚 梁荔燕 CHU Hong-xia, rao Zhi-gang ,LIANG Li-yan. (Department of Cardiology, Yantai Yuhuangding Hospital, Yantai 264000, China )
出处 《中国心血管杂志》 2006年第6期 439-442,共4页 Chinese Journal of Cardiovascular Medicine
关键词 心力衰竭 血管内皮生长因子 C-反应蛋白 Heart failure Vascular endothelial growth factor C-reaction protein
作者简介 初红霞(1972-),女,山东烟台人,2005年6月毕业于青岛大学医学院,硕士,主治医师,从事心内科专业。
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