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复方苦参注射液对结直肠癌肝转移肝动脉灌注化疗的影响 被引量:7

Effect of compound matrine injections on transhepatic artery chemoembolizatton of hepatic metastases from colorectal cancer
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摘要 目的探讨复方苦参注射液对结直肠癌肝转移肝动脉灌注及栓塞治疗(TACE)患者免疫功能及在化疗中的作用。方法32例行TACE治疗患者分为治疗组18例,对照组14例,治疗组用复方苦参注射液30ml,1次/d,共1周,对照组不用。观察治疗前后两组患者近期疗效、细胞免疫情况及化疗后毒副反应。结果治疗组近期疗效好于对照组(治疗组为66.7%,对照组为35.7%);治疗组Karnofsky评分提高率高于治疗前,对照组低于治疗前;治疗组CD3^+,CD4^+,CD8^+和NK细胞均值均有提高,与治疗前相比差异有统计学意义(P〈0.01);治疗组毒副作用较对照组轻。结论复方苦参注射液能提高近期疗效,提高患者机体免疫功能,减轻患者疼痛及化疗毒副作用。 Objective To explore the effect on immune function and the adjuvant effect during transhepatic artery chemoembolization (TACE) of compound matrine injections in patients with liver-only metastasis from colorectal cancer. Methods 32 patients with liver-only metastatic colorectal cancer were divided into treat ment group (18) and control group (14) at random. The treat ment group received TACE and compound matrine injections 30 ml per day for one week. The control group received TACE only. Then the curative effect in the near future, cell immune and toxicity after TACE were observed. Results The curative effect of the treat ment group was better than the control group(the treat ment group was 66.7 % and the control group was 35.7 %). Compared with pretherapy, the Karnofsky scores of the treat ment group increased while the control group decreased. The number of CD3^+, CD4^+, CD8^+ T cells and NK cells of the treatment group increased (P 〈 0.01). The toxicity was wilder in group A than that in group B. Conclusion Compound matrine injections can improve the curative effect and improve patients' immunity, and can lessen patients' pain and the side effect of chemotherapy.
作者 马建仓 戴社教 赵军 谢忠海 纪宗正 MA Jian-cang, DA I She-jiao, ZHAO Jun, XIE Zhong-hai, JI Zong-zheng (Department General Surgery, The 2nd Affiliated Hospitol of Xi'an Jiaotong University, Xi'an 710004, China)
出处 《肿瘤研究与临床》 CAS 2006年第12期 827-829,共3页 Cancer Research and Clinic
关键词 复方苦参注射液 结直肠癌 肝转移 肝动脉灌注化疗 Matrine injections Transhepatic artery chemoembolization Hepatic metastases Colorectal cancer
作者简介 通讯作者:马建仓,Email:majiancang@126.com;马建仓,男,博士在读,主治医师。
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