Objective To observe platelet aggregation in patient with coronary heart disease（CHD） using aspirin and clopidogrel after stenting. Methods ADP-induced and AA-induced platelet aggregation in 562 patients before and 3,7 days, 1,3,6 months after coronary stenting was studied. The patients were divided into two groups according to ADP-and AA-induced platelet aggregation inhibition 〈 40% or 〉140%. There were 75 patients in one group with ADP-induced platelet aggregation inhibition 〈 40% and 487 patients in another group with ADP-induced platelet aggregation inhibition ≥40%. There were 67 patients in one group with AA-induced platelet aggregation inhibition 〈 40% and 495 patients in another group with AA-induced platelet aggregation inhibition 〉140%. The main cardiovasular and cerebrovascular events 6 months after coronary stenting were observed. Results The patients in the two groups had similar clinical feature and there was no difference in other index （ P 〉 0.05）. The incidence of main cardiac events during 6-month follow-up was higher in the group with ADP-induced inhibition rate 〈 40% than in the group with inhibition rate≥40% （30.7% vs 12.9%, P 〈 0.05） The incidence was also higher in the group with AA-induced inhibition rate 〈 40% than in the group with inhibition rate ≥ 40 % （28.1% vs 11.7 %, P 〈 0. 05）. The adverse event of bleeding was not different. Conclusion There is correlation between the platelet inhibition rate and main heart and brain vascular events in CHD patients during 6 months after stenting.
Chinese Journal of Geriatric Cardiovascular and Cerebrovascular Diseases