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乳腺癌转移抑制基因作用机制 预览

Mechanism of breast cancer metastasis suppressor 1
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摘要 乳腺癌转移抑制基因(BRMS1)在人乳腺癌、黑色素瘤、膀胱癌、卵巢癌、嗜铬细胞瘤中具有抑制肿瘤细胞转移的能力,可明显减少转移灶的发生,作用机制复杂多样而又非典型,成为研究抑制肿瘤转移的新靶点。 Breast cancer metastasis suppressor 1 ( BRMS1 ) is identified as a novel metastasis suppressor gene,which suppresses metastasis of multiple human carcinomas such as breast cancer,melanoma, bladder cancer,ovarian cancer and pheochromocytoma. BRMS1 can reduce metastasis incidence significantly, but the mechanisms are complicated and atypical. BRMS1 is becoming a new target of inhibition of tumor metastasis.
作者 高华(综述) 狄文(审校) GAO Hua (Department of Obstetrics and Gynecology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200001, China)
出处 《国际肿瘤学杂志》 CAS 2007年第4期 261-264,共4页 Journal of International Oncology
基金 国家自然科学基金资助项目(30471808)
关键词 基因 肿瘤抑制 肿瘤转移 分子作用机制 Genes, tumor suppressor Neoplasm metastasis Molecular mechanism of action
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参考文献19

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