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2002-2005年北京儿童医院住院患儿病毒性脑炎流行病学分析 被引量:55

Epidemiological analysis of viral encephalitis in children hospitalized in Beijing Children's Hospital from 2002 to 2005.
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摘要 目的 了解北京地区儿童病毒性脑炎的流行病学特点。方法 对2002-01—2005-12在北京儿童医院住院治疗、出院诊断为病毒性脑炎的1016例进行回顾性总结分析,入选病例急性期血清和(或)脑脊液检测病毒IgM抗体,标本选择检测的病毒抗体种类按照临床医生的申请进行。结果 1016例病毒性脑炎患儿占住院总人数的1.0%,男女比例为2.2∶1,年龄(6.4±4.0)岁。血清和(或)脑脊液病毒抗体阳性的病例共380例(38.5%),其中肠道病毒抗体阳性病例最多(44.7%),其次是流行性腮腺炎病毒(35.3%),单纯疱疹病毒(15.5%),风疹病毒(4.5%),乙型脑炎病毒(2.9%)。1016例中,有3例死亡。结论 肠道病毒、流行性腮腺炎病毒和单纯疱疹病毒是北京地区儿童病毒性脑炎最常见的病原。该研究中62.6%的病例仍然缺乏病原学证据,因此需要建立针对更多病毒的快速敏感的检测方法从而为病毒性脑炎的诊断和治疗提供病原学证据。 Objective To better understand the epidemiological characteristics of viral encephalitis in children in Beijing area, Methods We analyzed all the patients hospitalized in Beijing Children's Hospital with the diagnosis of viral encephalitis from January 2002 to December 2005 retrospectively. Serum and/or CSF samples collected from those patients were selectively detected for IgM antibody to enteroviruses ( EV ) , cytomegalovirus ( CMV ) , herpes simplex virus ( HSV) , Epstein-Barr virus ( EBV ), varicella-zoster virus ( VZV ), human herpesvirus type 6 ( HHV-6 ), rubella virus ( RV ) , measles virus( MEA) ,mumps virus( MV) and Japanese encephalitis virus( JEV) according to the doctors applications. Results A total of 1 016 patients ( the male:female ratio was 2. 19:1 and the mean age was 6.4 ±4. 0 years) were treated for viral encephalitis in Beijing Children's Hospital,accounting for 1.03% of inpatients over the 4-year period. Specific IgM antibody in serum and/or CSF samples was positive in 380 cases ( 38. 5% ). Enteroviurses positive cases were the most (44. 7% ) ,followed by MV (35.3% ) ,HSV ( 15.5% ) ,RV (4. 5% ) ,JEV( 2. 9% ) ,while CMV,VZV and EBV positive cases were rare,totally 9 cases ( 2. 4% ). A fatal outcome was recorded for 3 cases. Conclusion EV, MV and HSV are the most important pathogens of viral encephalitis in children in Beijing area. The etiology still remains unknown for 62. 6% cases in our study so more rapid and sensitive diagnostic methods screening for a wide range of viruses are needed to be set up to provide useful etiological evidence for diagnosis and treatment.
作者 刘春艳 申昆玲 梁国栋 LIU Chun-yan , SHEN Kun-ling,LIANG Guo-dong. (Beijing Children's Hospital, Capital Medical University,Beijing 100045, China)
出处 《中国实用儿科杂志》 北大核心 2007年第7期498-501,共4页 Chinese Journal of Practical Pediatrics
关键词 病毒性脑炎 儿童 流行病学 Viral encephalitis Children Epidemiology
作者简介 E-mail : chunyan73 @ hotmail.com
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参考文献16

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