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疏肝活血汤抑制动脉粥样硬化家兔IGF-1和TG表达的报告 预览 被引量:4

Effect of Shuganhuoxue Decoction on IGF-1 Gene Expression of Vessel Wall in Atherosclerotic Rabbit
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摘要 目的观察动脉粥样硬化家兔胰岛素样生长因子-1(IGF-1)和TG的表达情况及疏肝活血汤对其抑制效果。方法将32只健康新西兰大耳白兔随机分为4组:正常对照组(A)、模型组(B)、西药组(C)和中药组(D),分别给予普通饲料、高脂饲料、高脂饲料加来适可胶囊和高脂饲料加疏肝活血汤灌胃喂饲。实验第5周,B、C、D组均行右侧腹-髂动脉内膜球囊损伤术。7周末采血检测三酰甘油、总胆固醇、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇,并用免疫组化方法观察血管平滑肌细胞IGF-1的表达。结果正常组、西药组、中药组和模型组IGF-1的含量依次为(0.038±0.009)、(0.122±0.009)、(0.112±0.007)和(0.167±0.016)μg/L,模型组表达量高于中药组及西药组(P〈0.05)。中药组和西药组LDL-C检测值低于模型组而高于正常组,差异有统计学意义(P〈0.01)。结论疏肝活血中药可以抑制血管平滑肌细胞TGF-1的表达,并降低其LDL-C含量,阻断血管平滑肌细胞增殖的关键环节,并从而阻止动脉粥样硬化发生发展。 Objective In this study, the effect of shuganhuoxue(SGHXT) on Insulin-like growth factor-1 ( IGF-1 ) expression of vessel wall was explored with immunity histeehemistry. Method 32 healthy rabbits were randomly divided into four groups: Normal control group(A), Model group(B), Fluvastatin group(C) and SGHXT greup(D).The four groups were given ordinary feed, high fat diet, high fat diet with Fluvastatin capsules, high fat diet with SGHXT. Mter 5 weeks, group B, C and D were given Right abdomeniliac artery balloon injury of endometrial. After 7 weeks, group A, B, C and D were collected blood samples, tested lipid and explored Insulin-like growth factor-1 (IGF-1 ) expression of vessel wall with immunity histochemistry. Result The results showed that the IGF-1 expression in model group was enhanced than that in the normal group. However, the expression in SGHXT group decreased less than that in the model group. Conclusion It suggested that one of the effect of SGHXT on preventing VSMC proliferation was its influence on IGF-1 mRNA expression level.
作者 赏楠 杨关林 孙秀业 SHANG Nan, FANG Guan-lin , SUN Xiu-ye ( 1. The Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang 110032, China; 2. The Second Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang 110032, China)
出处 《医学综述》 2008年第3期 474-476,共3页 Medical Recapitulate
关键词 疏肝活血汤 动脉粥样硬化 胰岛素样生长因子 Shuaanhuoxue decoction: Atheroscleresis Insulin-like growth factor-1
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