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外周性原始神经外胚层肿瘤皮下埋植式动脉化疗的临床观察 预览 被引量:3

Clinical observation on intra-arterial chemotherapy by subcutaneous implantable delivery system for treatment of peripheral primitive neuroectodermal tumors
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摘要 目的 观察外周性原始性神经外胚层肿瘤(pPNET)皮下埋植式动脉化疗的疗效。方法 外周性原始神经外胚层肿瘤8例,男6例,女2例;中位年龄12.4岁。经皮下埋植式给药装置行阿霉素、顺铂联合咖啡因导向性灌注3~4次,化疗后进行手术或放射综合治疗。结果 化疗后疼痛完全缓解;肿瘤病灶CR3例,PR5例,有效率100%。平均生存28.4个月,生存率37.5%。结论 pPNET是一种极度恶性的小圆细胞肿瘤,皮下埋植式动脉化疗是一种有效的化疗方法,但还要辅以手术和放射治疗。 Objective To observe the clinical results of intra-arterial chemotherapy by subcutaneous implantable delivery system in the treatment of perpheral primitive neuroectodermal tumours (pPNETs). Methods Eight cases of pPNET(male 6 cases, female 2 cases, average age was 12.4 years ) were treated with cisplatin, adriamycin and caffeine targeting infusion by subcutaneous implantable intra-arterial drug delivery system for 3-4 times. Operation or radiation was given after chemotherapy. Results Total effective rate (CR) of relieving pain was 100%. CR of tumor was found in 3 cases,PR 5 cases,RR 100%. Average survival period was 28.4 months, rate of survival was 37.5%. Conclusion pPNET is a kind of malignant small round cell tumor with rapid aggressive clinical course. Intra-arterial chemotherapy by subcutaneous implantable delivery system is an effective treatment method. Operation or radiation is also necessary for auxiliary treatment.
作者 范海涛 李鼎锋 刘蜀彬 王磊 崔秋 张平 周举 刘铖 姜维浩 曹云岑 FAN Hai-tao ,LI Ding-feng,LIU Shu-bin ,et al ( Department of Orthopedics, Affiliated 307 Hospital of PLA, Academy of Military Medical Sciences, Beijing 100071, China)
出处 《中国肿瘤临床与康复》 2008年第1期 38-41,共4页 Chinese Journal of Clinical Oncology and Rehabilitation
关键词 外周性原始神经外胚层肿瘤 介入化疗 咖啡因 pPNET Intra-arterial chemotherapy Caffeine
作者简介 范海涛,男,硕士,主治医师,从事骨科专业。
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参考文献9

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共引文献30

同被引文献21

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