目的 观察外周性原始性神经外胚层肿瘤（pPNET）皮下埋植式动脉化疗的疗效。方法 外周性原始神经外胚层肿瘤8例，男6例，女2例；中位年龄12．4岁。经皮下埋植式给药装置行阿霉素、顺铂联合咖啡因导向性灌注3～4次，化疗后进行手术或放射综合治疗。结果 化疗后疼痛完全缓解；肿瘤病灶CR3例，PR5例，有效率100％。平均生存28．4个月，生存率37．5％。结论 pPNET是一种极度恶性的小圆细胞肿瘤，皮下埋植式动脉化疗是一种有效的化疗方法，但还要辅以手术和放射治疗。
Objective To observe the clinical results of intra-arterial chemotherapy by subcutaneous implantable delivery system in the treatment of perpheral primitive neuroectodermal tumours （pPNETs）. Methods Eight cases of pPNET（male 6 cases, female 2 cases, average age was 12.4 years ） were treated with cisplatin, adriamycin and caffeine targeting infusion by subcutaneous implantable intra-arterial drug delivery system for 3-4 times. Operation or radiation was given after chemotherapy. Results Total effective rate （CR） of relieving pain was 100%. CR of tumor was found in 3 cases,PR 5 cases,RR 100%. Average survival period was 28.4 months, rate of survival was 37.5%. Conclusion pPNET is a kind of malignant small round cell tumor with rapid aggressive clinical course. Intra-arterial chemotherapy by subcutaneous implantable delivery system is an effective treatment method. Operation or radiation is also necessary for auxiliary treatment.
Chinese Journal of Clinical Oncology and Rehabilitation