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基于颞叶癫痫脑电相位互相关分析法的癫痫超同步放电的初步研究 被引量:2

Study on hypersynchronous discharge based on the cross-correlation analysis of EEG phases of temporal lobe epilepsy
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摘要 目的分析颞叶癫痫患者病灶区和非病灶区脑电相位的同步关系,并与正常对照者比较,为癫痫发作的超同步放电机制提供支持。方法选择经临床确诊且责任病灶为左颞区的颞叶癫痫患者20例和正常对照者10例,双侧颞区各放置4个记录电极,电极间距为20mm。应用Hilberr变换提取以上脑电的相位,应用互相关方法分别计算左右两侧颞区每个区内每两导脑电相位间的互相关系数,结果用统计软件SPSS10.0处理。结果颞叶癫痫组病灶区与正常组左颞区脑电相位的平均互相关系数比较有显著性差异(P〈0.01);两组右侧脑电相位的平均互相关系数比较有显著性差异(P〈0.05)。颞叶癫痫组病灶区与非病灶区脑电相位的平均互相关系数比较有显著性差异(P〈0.05);正常组两侧脑电相位的平均互相关系数比较无显著性差异。正常组脑电相位的最大互相关系数均位于两个相邻导联间.颞叶癫痫组37.5%的位于相隔导联间。结论颞叶癫痫病灶区存在超同步放电现象,非病灶区也存在不同程度的超同步放电。 Objective To study the bilateral temporal EEG phases of the temporal lobe epilepsy (TLE) patients to support that the hypersynchronous discharge is one of the causes of seizure. Methods Thirty human subjects participated in the study. TLE group (n=20) were TLE patients with left epileptogenic focus. Control group (n=10) were healthy volunteers. Bilateral temporal EEGs were recorded with MR-95 Recorder (Oxford Company). Four Ag/Agcl electrodes were placed bilaterally on the subject's temporal areas, the distance of any adjacent electrodes was 20 ram. The phases of these EEGs were extracted with Hilbert transform. We compared cross-correlation coefficients of all subjects. Statistical analysis was carried out with SPSS 10.0. Results The statistical analysis of the mean EEG phases cross-correlation coefficients between adjacent recording electrodes showed that there was significant difference in the left and right temporal areas between the TLE group and the control group (P〈0.01, P〈0.05), and also significant difference between left (epileptic focus) and right (non-focus) temporal areas in the TLE group (P〈0.05), while there was no significant difference between left and right temporal areas in the control group. Maximum phases cross-correlation coefficients were situated at adjacent recording electrodes in the control group, while 37.5% were separated in the TLE group. Conclusions There were the occurrences of hypersynchronous discharge in the epileptic focus and inferior hypersynchronous discharge in the non-focus.
作者 崔林阳 田心 CUI Lin-yang, TIAN Xin. (Department of Neurology General Hospital, Tianjin Medicol University, Tianjin Neurological Institute, Tianjin 300052, China)
出处 《中华神经医学杂志》 CAS CSCD 2008年第3期219-222,共4页 Chinese Journal of Neuromedicine
关键词 癫痫 颞叶 脑电图 超同步放电 互相关系数 Epilepsy, temporal lobe Electroencehalogram Hypersynchronous discharge Cross-correlation coefficients
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  • 1Schreiber T. Measuring information transfer[J]. Phys Rev Lett, 2000, 85(2): 461-464. 被引量:1
  • 2Beylkin G, Mohlenkamp MJ. Numerical operator calculus in higher dimensions [J]. Proc Natl Acad Sci USA, 2002, 99 (16): 10246-10251. 被引量:1
  • 3Mormann F, Kreuz T, Andrzejak RG, et al. Epileptic seizures are preceded by decrease in synchronization[J]. Epilepsy Res, 2003, 53 (3): 175-185. 被引量:1
  • 4Gong P, Nikolaev AR, van Leeuwen C. Scale-invariant fluctuations of the dynamical synchronization in human brain electrical activity [J]. Neurosci Lett, 2003, 336(1): 33-36. 被引量:1
  • 5Fingelkurts AA, Fingelkurts AA, Kivisaafi R, et al. Local and remote functional connectivity of neocortex under the inhibition influence[J]. Neuroimage, 2004, 22(3): 1390-1406. 被引量:1
  • 6大熊辉雄.临床脑电图学[M].北京:清华大学出版社,2005:69-76. 被引量:13
  • 7刘秀琴.神经系统临床电生理学[A].见:王维治.神经病学[M].北京:人民卫生出版社,2004.127-146. 被引量:1
  • 8Koivisto M, Revonsuo A. Cognitive representations underlying the N400 priming effect[J]. Brain Res Cogn Brain Res, 2001, 12(3): 487-490. 被引量:1
  • 9Fingelkurts A, Fingelkurts A, Krause C, et aL Structural (operational) synchrony of EEG alpha activity during an auditory memory task [J]. Neuroimage, 2003, 20(1): 529-542. 被引量:1
  • 10Freeman WJ, Holmes MD, West GA, et al. Fine spatiotemporal structure of phase in human intracranial EEG [J]. Clin Neurophysiol, 2006, 117(6): 1228-1243. 被引量:1

二级参考文献20

  • 1Drongelen W,Lee HC,Hereld M,et al.Emergent epileptiform activity in neural networks with weak excitatory synapses.IEEE Trans Neural Syst Rehabil Eng,2005,13 (2):236-241. 被引量:1
  • 2Garcia Dominguez L,Wennberg RA,Gaetz W,et al.Enhanced synchrony in epileptiform activity ? Local versus distant phase synchronization in generalized seizures.J Neurosci,2005,25(35):8077-8084. 被引量:1
  • 3Mormann F,Kreuz T,Andrzejak RG,et al.Epileptic seizures are preceded by a decrease in synchronization.Epilepsy Res,2003,53(3):173-185. 被引量:1
  • 4Avoli M,Louvel J,Mattia D,et al.Epileptiform synchronization in the human dysplastic cortex.Epileptic Disord,2003,5(s2):S45-S50. 被引量:1
  • 5Avoli M,D'Antuono M,Louvel J,et al.Network and pharmacological mechanisms leading to epileptiform synchronization in the limbic system in vitro.Prog Neurobiol,2002,68(3):167-207. 被引量:1
  • 6Bartolomei F,Wendling F,Regis J,et al.Pre-ictal synchronicity in limbic networks of mesial temporal lobe epilepsy.Epilepsy Res,2004,61(1-3):89-104. 被引量:1
  • 7Benini R,Avoli M.Rat subicular networks gate hippocampal output activity in an in vitro model of limbic seizures.J Physiol,2005,566(Pt 3):885-900. 被引量:1
  • 8Klueva J,Munsch T,Albrecht D,et al.Synaptic and nonsynaptic mechanisms of amygdala recruitment into temporolimbic epileptiform activities.Eur J Neurosci,2003,18(10):2779-2791. 被引量:1
  • 9Neder L,Valente V,Carlotti CG Jr,et al.Glutamate NMDA receptor subunit R1 and GAD mRNA expression in human temporal lobe epilepsy.Cell Mol Neurobiol,2002,22 (5-6):689-698. 被引量:1
  • 10]Arabadzisz D,Antal K,Parpan F,et al.Epileptogenesis and chronic seizures in a mouse model of temporal lobe epilepsy are associated with distinct EEG patterns and selective neurochemical alterations in the contralateral hippocampus.Exp Neurol,2005,194(1):76-90. 被引量:1

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