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低分子肝素在经皮冠状动脉成形术中应用的临床观察 预览

Rudiment clinical observation of the application of low molecular weight heparins in percutaneous coronary intervention
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摘要 目的探讨低分子肝素在经皮冠状动脉成形术(PCI)中应用的有效性和安全性。方法将2002年4月至2007年7月收治的共224例行PCI术的患者分为普通肝素组和低分子肝素组。普通肝素组103例,其中男78例,平均年龄65.6±10岁。低分子肝素组121例,其中男92例,平均年龄(64±10)岁。结果两组的一般临床资料比较差异无显著性。两组手术成功率为98.4%和98%。7d内主要心血管事件各2例,急性血栓形成均0例,周围血管并发症8例与4例,两组比较差异无统计学意义(P〉0.05)。结论低分子肝素在PCI中的应用是有效的、安全的。 Objective To invetigate the effectiveness and safety of low molecular weight heparins application in PCI. Methods 224 PCI patiens who were hospitalized from. Apr. 2002 to Jul. 2007 in Huludao Hospital with divided intotwo groups which were using common depo-heparin, and group which were using low-molecular- weight heparins. There were 103 patiens in group which were using common depo-heparin,78 males, average age 65.6 ± 10 and 121 patiens in group which were using low-molecular-weight heparins. 92 males, average age 64 ± 10. Results Clinical data obtained from the two groups has no significant difference. The success rate of operation (98.4% vs 98.0% ), target vessel revascularization within7 days ( 2 vs patients), acute thrombosis (0 pstients in both groups)and peripheral vascular complications( 8 vs 4 patients)of the two groups have no significant difference (P 〉 0.05). Conclusion Using low molecular weight heparins in PCI is effective and safe.
作者 赵晓峰 ZHAO Xiao-feng. (Departmentof Cardiology, Centra Hospital of Huludao City, liaoning125001, China )
出处 《中国现代药物应用》 2008年第4期 13-14,共2页
关键词 肝素 低分子 血管成行术 经腔 经皮冠状动脉 Heparin Low-olecular-weight Angioplasty Transluminal Percutaneous coronary
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参考文献3

  • 1[1]Collet JP,Montalescot G,Lison L,et al.Percutaneouscoronary intervention after suboutaneous enoxaparin pretreatment in patients with unstable angina pectors.Circulation,2001,103:658-663. 被引量:1
  • 2[2]Wong GC,Giugliano RP,Antman EM.Use of low molecular weight heparins in the management of acute coronary artery syndromes and percutaneous coronary intervention.JAMA,2003,289:331-342. 被引量:1
  • 3[3]Chen WH,Lau CP,Lau YK,et al.Stable and optimal anticoagulation is achieved with a single does of intravenous enoxaparin in patients undergoing percutaneous coronary intervention.J Invasive Cardiol,2002,14:439-442. 被引量:1
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