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依那普利对NIDDM患者糖代谢的影响 被引量:38

EFFECT OF ENALAPRIL ON GLUCOSE METABOLISM IN NORMOTENSIVE NIDDM PATIENTS
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摘要 应用依那普利(20mg/d)或安慰剂对34例不伴有高血压的非胰岛素依赖型糖尿病(NIDDM)患者进行了6个月治疗,结果显示依那普利治疗后NIDDM患者血糖、糖化血红蛋白、血浆胰岛素水平明显减低,外周胰岛素敏感度显著升高,而胰岛素释放率、血压及肾功能均无明显变化。本资料表明,依那普利能够提高NIDDM患者外周组织对胰岛素的利用,降低外周胰岛素抵抗,改善葡萄糖代谢。 To determine the effects of the angiotensin_converting enzyme inhibitor, enalapril, on insulin action and glycemic control in normotensive NIDDM patients, a single_blind, placebo_controlled trial was conducted in 34 such subjects who were given either enalapril (20 mg/d) or placebo for six months. Both insulin release and the degree of peripheral insulin sensitivity were evaluated simultaneously with oral glucose tolerance test. At the end of the study, the levels of blood glucose, glycated hemoglobin and plasma insulin decreased markedly and the degree of peripheral insulin sensityvity increased significantly in the enalapril_treated patients, as compared with the pre_treatment values in the enalapril group and with the as placebo_treated patients. The insulin release, renal function and blood pressure remained unchanged after enalapril treatment. The results suggest that long_term enalapril administration enhances utilization of insulin by peripheral tissues, decreases peripheral insulin resistance and improves glucose metabolism.
作者 毛晓明 饶亚萍 Mao Xiaoming,Yao Yaping,Gu Yianyian,et al.Department of Endocrinology,PLA NO.454 Hospital,Nanjing,210002.
出处 《中华内分泌代谢杂志》 CAS CSCD 北大核心 1997年第3期 151-153,共3页 Chinese Journal of Endocrinology and Metabolism
关键词 依那普利 非胰岛素 依赖型 糖尿病 糖代谢 Enalapril NIDDM Insulin resistance Glucose metabolism
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