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H2O2浸渍处理对水牛角胎力学特性的影响 预览

Effect on the mechanical characteristics of matrix in buffalo cornu soaked by hydrogen peroxide
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摘要 背景:前期实验数据证明,水牛角胎的形态结构、理化参数、生物性质、力学性能等方面具有良好的骨科生物材料的特征。 目的:拟观察脱蛋白处理水牛角胎后,其抗原性和生物力学强度与经30%H2O2处理的时间关系。 设计、时间及地点:测量实验,于2000-02/03在昆明理工大学力学试验室完成。 材料:水牛来源于云南省泸西县屠宰场,取水牛角胎制成公称尺寸试件。 方法:试件经热蒸馏水反复冲洗后,用氯仿-甲醇1:1浸渍48h,再用体积分数为0.3的H2O2浸渍,实验组分别处理24,48h,另设未经任何处理试件为对照组。 主要观察指标:电测试法测定弹性模量E;直接加压法测其抗压强度。 结果:各组间弹性模量相比,差异均无显著性意义(P〉0.05)。对照组的抗压强度明显高于实验组(P〈0.01),24h实验组与48h实验组间抗压强度相比,差异无显著性意义(P〉0.05)。 结论:水牛角胎经H2O2浸渍48h处理,保留了较好的生物力学强度。 BACKGROUND: Previous research reveals that, the morphous, structure, physicochemical property and mechanical characteristics of matrix in buffalo cornu all contribute to the biomaterials in the field of orthopaedics. OBJECTIVE: To investigate the correlation between the duration of matrix in buffalo cornu soaked in 30% hydrogen peroxide and the antigenicity, the biomechanical intensity of matrix in buffalo cornu treated by deproteinization. DESIGN, TIME AND SETTING: Measurement experiments were performed in the Mechanics Laboratory, Kunming University of Science and Technology (Kunming, Yunnan, China) from February to March in 2000. MATERIALS: Buffalo was provided by Luxi Abattoir of Yunnan Province (China), and then processed into test pieces at a nominal thickness. METHODS: The metric test pieces were rinsed with distilled water and soaked by chloroform-methyl alcohol at a ratio of 1:1 for 48 hours, then in 30% hydrogen peroxide for 24 and 48 hours, which served as the experimental group. While those remaining untreated were taken as controls. MAIN OUTCOME MEASURES: The modulus of elasticity and compressive strength were measured by electric measurement method and direct pressurization method, respectively. RESULTS: The modulus of elasticity between the experimental group and the control group had no significant difference (P 〉 0.05). The compressive strength in the control group was significantly higher than that in the experimental group (P 〈 0.01), and there were no significant differences between the experimental group treated for 24 hours and the experimental group treated for 48 hours (P 〉 0.05). CONCLUSION: Subsequent to soaking in 30% hydrogen peroxide for 48 hours, the matrix in buffalo cornu maintains better biomechanical intensity.
作者 郭毅 郭琛琨 Guo Yi, Guo Chen-kun(1Department of Traumatology, Second People's Hospital of Yunnan Province, Kunming 650021, Yunnan Province, China; 2Xiyuemiao Sanatorium for Retired Cadre. Chengdu Military Area Command of Chinese PLA, Kunmmg 650034, Yunnan Province, China)
出处 《中国组织工程研究与临床康复》 CAS CSCD 北大核心 2008年第23期 4597-4600,共4页 Journal of Clinical Rehabilitative Tissue Engineering Research
基金 Acknowledgement Thanks for Wen Hong-guang and Luo Cheng-ling et al in the Kunming University of Science and Technology with regard to the mechanical experiments.
作者简介 郭毅、男,1958年生,湖北省枣阳市人,汉族,1986年同济医科大学郧阳医学院毕业,副主任医师,主要从事多发伤救治,骨缺损修复的研究。
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参考文献5

  • 1Guo CK, Tang XL, Lu Y, et al. Experiment research on rebuild bone defect by regeneration of transplantation bone of matrix in buffalo cornu. Zhonghua Waike Zazhi 2003;41 (3):239-240 被引量:1
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