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小月龄婴儿麻疹母传抗体消长研究 被引量:108

Study on Changing of Maternal Transferred Measles Antibody Level in Infants
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摘要 目的对母婴麻疹抗体水平及其关系,婴儿胎传抗体衰减进行分析,探讨小月龄婴儿麻疹减毒活疫苗(Measles Vaccines,Live;MV)的免疫策略。方法在浙江省宁波市、山东省济南市、黑龙江省哈尔滨市选取0、3、6、8、9月龄未患过麻疹的本地常住婴儿及母亲作为研究对象,采用酶联免疫吸附试验检测麻疹IgG抗体。结果婴儿出生时麻疹抗体阳性率为89.3%,几何平均滴度(Geometric Mean Titer,GMT)为1:738.93,到3月龄时抗体阳性率下降至22.3%,GMT为1:36.63,6、8月龄时抗体阳性率只有6.9%、6.7%,GMT分别为1:6.89、1:3.69;母亲的抗体阳性率为84.3%,GMT为1:516.94;母婴麻疹抗体的相关系数为0.840。结论降低小月龄麻疹发病,必要时对6月龄婴儿实行MV初免以提高保护率,同时提高育龄期妇女麻疹抗体水平。 Objective To determine the relative immunity policies of measles vaccines(live; MV) in infant through analyzing the antibody level of maternal-infant and the change in infants. Methods Newborn,3,6,8,9-month infant who never had measles and their mothers who were residents in Ningbo Zhejiang, Harbin Heilongjiang and Jinan Shandong were selected as targeted population. Their serum samples were tested by the method of ELISA. Results The positive rate and GRMT of measles antibody in newborns were 89.3% and 738. 93 respectively,which reduced to 22.3% and 516.94 by 3 months; and decreased to 6.97%, 6.7% GRMT were 1 : 6.89, 1,3.69 by 6month and 8month respectively. The positive rate and GRMT of measles antibody in mothers were 84.3 and 516.94. The correlation coefficient between mother and infant was 0. 840. Conclusions In order to decrease the incideule of measles in infants, first dose measles vaccine can be ingected to 6month infants when it is necessary so that to increase protection rate. It is neceseary to increase the level of antibody to the reproductive women as well.
作者 马瑞 许国章 徐宏杰 马衍辉 董红军 李岩 胡风霞 倪红霞 边国林 梁英 刘岚铮 周绍英 怀清杰 韩秀云 MA Rui, XU Guo- zhang,XU Hong-jie, et al. ( Ningbo City Center for Disease Control and Prevention, Ningbo 315010, Zhejiang, China)
出处 《中国疫苗和免疫》 CAS 2008年第3期226-228,共3页 Chinese Journal of Vaccines and Immunization
基金 联合国儿童基金会资助项目(志谢:感谢卫生部、联合国儿童基金会资助及中国CDC的支持和技术指导,感谢3个市及有关县、市、区CDC的大力协助!)
关键词 麻疹 婴儿母传抗体 免疫策略 Measles Maternal transferred antibody Infant Immunity policy
作者简介 马瑞(1969-),女,甘肃省天水市人,浙江省宁波市疾病预防控制中心副主任医师,硕士,主要从事免疫规划针对传染病的预防控制工作。 通讯作者:许国章
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