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肺癌患者血液高凝状态的临床意义 预览 被引量:9

Clinical Significance of Hypercoagulable State in Patients with Lung Cancer
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摘要 目的探讨肺癌患者血小板CD62p表达、血浆纤维蛋白原(FIB)、D-二聚体(D-D)及vWF水平与肺癌及其病情之间的关系。方法采用EPICS XL流式细胞仪检测41例初诊肺癌,18例其它恶性肿瘤以及36例良性肺疾病患者血小板CD62p表达水平,用ACL Advance血凝分析仪检测血浆FIB、D-D和vWF水平。结果肺癌组CD62p,FIB,D-D及vWF水平比良性肺病和正常对照组显著升高(P〈0.01),与其他肿瘤组比较,肺癌组CD62p,HB和mD水平显著升高(P〈0.05)。化疗前,FIB升高组和有转移组CD62p,FIB,D-D及vWF水平分别显著高于FIB正常组和无转移组(P〈0.01),化疗后4组各指标均显著降低(P〈0.01),但HB升高组与有转移组仍显著高于正常对照组(P〈0.01)。4种指标各种组合中,伴CD62p表达增高的患者百分率最高。4种指标相互间呈明显的正相关(P(0.05)。结论CD62p表达水平在肺癌患者病情观察中具有重要意义,综合分析CD62p,FIB,D-D及vWF水平,可用作判断肺癌患者体内高凝和纤溶状态,估计病情和观察疗效。 Objective To explore the relationship between the levels of platelet granule membrane protein - 140 (CD62p), fibrinogen (FIB), D- dimer (D- D), yon Willebrand factor (vWF) and lung cancer. Methods EPICS XL flow cytometry arid ACL Advance blood coagulation analyzer were applied to detect the levels of CD62p expression and FIB, D- D, vWF, respectively, in 41 patients with lung cancer, 18 patients with other malignant tumor, 36 patients with benign pulmonary disease and 30 normal controls. Results The levels of CD62p expression, FIB, D - D and vWF were significantly higher in patients with lung cancer than in patients with benign pulmonary diseases and normal controls (P 〈 0.01). Comparing with the patients with other malignant tumor, the levels of CD62p expression, FIB and D- D were significantly higher in patients with lung cancer. Before chernotherapy, all of the levels of CD62p, FIB, D - D and vWF were significantly higher in both of patients with high level of FIB and with tumor metastasis than in patients with normal level of FIB and without tumor metastasis, respectively (P 〈0.05). The same tendency also could be observed after chemotherapy, although all of the levels of CD62p expression, FIB, D - D and vWF significantly decreased (P 〈 0.01 ). Conclusion The level of CD62p is important for the clinical significance of patients with lung cancer. The comprehensive analysis of the indices of CD62p, FIB, D- D and vWF can be used to evaluate the blood coagulation and fibrinolysis state and observe disease stage and therapeutic effects on patients with lung cancer.
作者 费鲜明 潘建平 FEI Xian-ming,PAN Jian - ping. (Department of Basic medical of Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310058, China. )
出处 《浙江预防医学》 2008年第11期 10-12,共3页 Zhejiang Journal of Preventive Medicine
关键词 肺癌 高凝状态 CD62P 纤维蛋白原 转移 lung cancer Hypercoagulable state CD62p Fibrinogen Metastasis
作者简介 浙江省人民医院在职研究生
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